通淋胶囊对豚鼠steblay型间质性肾炎的影响  

Effect Of TongLin Capsule On Type Steblay Interstitial Nephritis Of Cavy

作　　者：张艳[1] 朱建立[1] 戈士文[1] 腊胜明[1] 李月华[1] 

机构地区：[1]河南省医学科学研究所,河南郑州450052

出　　处：《中成药》2001年第1期41-42,共2页Chinese Traditional Patent Medicine

基　　金：河南省科委重点资助项目,编号 981170 72 5

摘　　要：目的 :观察通淋胶囊对豚鼠steblay型间质性肾炎的影响。 方法 :用兔肾皮质中肾小管的基底膜与弗氏完全佐剂免疫豚鼠 ,造成自身免疫肾小管间质性肾炎动物模型 ,观察通淋胶囊对其肾脏病变的影响。结果 :①各治疗组动物的Cr及BUN均明显低于模型组 (P <0 .0 5或 0 .0 1)。②肾病理组织学检察 ,低剂量组动物在肾间质内可见散在的炎症细胞浸润 ,高剂量组动物肾间质内无明显异常发现。结论 :通淋胶囊能改善肾功能 。Objective:The effect of Tonglin capsule was observed on type steblay interstitial nephritis of cavy.Methods: The cavy was immunized using the basement membrane of renal tubule from renal cortex of rabbit and Freund's complete adjuvant (FCA). The animal model of autoimmunity renal tubule interstitial nephrifis was made, The effect of Tonglin capsule on nephric pathological changes was observed. Results: ① The levels of creatinine (Cr) and blood uria nitrogen (BUN) in treatment groups were obviously lower than that in model group ( P <0.05 or 0.01 ); ② renal histopathological examination showed that dispersed inflammatory cell infiltration in renal interstitial of lower does group animals could be seen, but no obviously anomaly was discovered in renal interstitial of higher does group animals. Conclusions: Tonglin capsule could improve renal function, and obviously lessen the damage of renal interstitial and renal tubules.

关 键 词：通淋胶囊 豚鼠 间质性肾炎 

分 类 号：R969[医药卫生—药理学]