南昌链霉菌生物合成梅岭霉素种子制备优化  

Optimization of seed preparation for meilingmycin production of Streptomyces nanchangensis

作　　者：陈斌[1,2] 庄英萍[1] 郭美锦[1] 储炬[1] 张嗣良[1] 

机构地区：[1]华东理工大学生物反应器工程国家重点实验室国家生化工程技术研究中心 [2]西北大学化学工程系,西安710069

出　　处：《中国抗生素杂志》2003年第11期641-644,共4页Chinese Journal of Antibiotics

基　　金：国家"十.五"科技攻关资助项目(No.2002BA708B07-05)。

摘　　要：以参数相关理论为指导,优化南昌链霉菌生物合成梅岭霉素种子制备工艺。结果表明,培养20～35h后,pH7.30～7.50,总糖<0.35%,pmv>10%,溶磷<100μg/ml,菌丝分化启动有利于提高梅岭霉素的发酵效价。Based on parameter dependent theory,seed preparation was optimized in the process of meilingmycin biosynthesis by Streptomyces nanchangensis.Experimental results showed that pH=7.30 7.50,the concentration of total sugar < 0.35% ,pmv > 10% ,soluble phosphate < 100μ g/ml and phosphate< 100μ g/ml and as well as in the state of the onset of mycelium differentiation could lead to high production of meilingmcyin after 20～ 35 hour's seed culture.

关 键 词：梅岭霉素 种子 优化 参数相关 

分 类 号：R978.15[医药卫生—药品]