肿瘤坏死血清诱生条件及小鼠体内抗疟原虫作用  

INDUCTION CONDITION OF TUMOR NECROSIS SERUM AND ITS ANTIPLASMODIUM FUNCTION IN VIVO

作　　者：姚彦明[1] 毛兰芝[1] 王全德[1] 候广培 崔祖让 蔡访勤 

机构地区：[1]新乡医学院微生物学与免疫学教研室 [2]河南省卫生防疫站 [3]河南医科大学

出　　处：《新乡医学院学报》1992年第3期191-193,共3页Journal of Xinxiang Medical University

摘　　要：本文就含肿瘤坏死因子(TNF)的肿瘤坏死血清(TNS)产生的适宜条件及小鼠体内抗疟原虫作用进行研究。结果表明:NZW兔在卡介苗(BCG)注射二周后经细菌内毒素(LPS)攻击1.5小时在其血清中出现最高活性TNF;TNS对感染疟原虫小鼠体内实验显示:实验组与对照组小鼠疟原虫血症有显著性差异,提示TNS有体内抗疟原虫作用。The condition for induction of tumor necrosis serum (TNS) containing tumor necrosis factor (TNF) in NZW rabbits and its antiplasmodium activity in vivo were studied. The results show that the most active TNF presents in the serum-of NZW rabbit which was infected with BCG for 2 weeks and then challenged with LPS for 1.5 hours. The parasitemia of experimental mice presented 2 days late compared with control grop.TNS decreased the parasitemia of experimental mice until 10th day (P<0.05).The survial time of two groups had significant difference (P<0.05).

关 键 词：肿瘤坏死血清 肿瘤坏死因子 疟原虫 

分 类 号：R392－33[医药卫生—免疫学]