阿米洛利与氨苯蝶啶治疗原发性高血压545例的比较  

Comparison between amiloride and triamterene in treatment of 545 patients with essential hypertension

作　　者：陆德澄[1] 金妙珍[2] 张子沪[3] 赵福全[4] 杨显祖[5] 朱剑秋[6] 洪立基[7] 

机构地区：[1]镇江医学院附院,镇江212001 [2]南京鼓楼医院,南京210008 [3]南京铁道医学院附院,南京210009 [4]扬州医学院附院,扬州225000 [5]常州市第一人民医院,常州213003 [6]无锡市第一人民医院,无锡214002 [7]南京医学院,南京210004

出　　处：《新药与临床》1992年第6期337-341,共5页

摘　　要：对545例轻、中型高血压患者,其中Ⅰ组134例(男88例,女46例;年龄50±9a)采用阿米洛利片5mg/d;Ⅱ组139例(男90例,女49例;年龄51±10a)采用氨苯喋啶片50mg/d;复Ⅰ组159例(男103例,女56例;年龄51±8a)采用复方阿米洛利片1片/d;复Ⅱ组113例(男69例,女44例;年龄51±9a)采用复方氨苯喋啶片1片/d;疗程均2mo。结果:总有效率Ⅰ组优于Ⅱ组(67.2％对49.6％);复Ⅰ组优于复Ⅱ组(83.0％对69.9％);P值均<0.01。In randomized trial on 545 patients with mild or moderate essential hypertension, group I (134 patients) received amiloride (Ami) 5 mg/d; group Co I (159 patients) received Ami 5 mg + hydrochlorothiazide (HCT) 50 mg/d;group II-(139 patients) received triamterene (Tri) 50 mg/d; group Co II (113 patients) received Tri 50mg+HCT 25 mg/d. Each drug was given for 2 mo. The blood pressure results showed that (1) the response rate in group I (67.2%) was better than in group II (49.6%) (P<0.01); (2) the response rate in group Co I (83.0%) was better than in group Co II (69.9%) (P<0.01). Serum potassium level increased around 0.17-0.22 mmol/L after 2 mo treatment in all 4 groups. Hypokalemia and abnormal U wave, ST segment and T wave in ECG mostly became normal. No serious adverse effects were seen and both Ami and Tri were well tolerated. Thus Ami or Ami plus HCT exerted better effects than Tri.

关 键 词：阿米洛利 氨苯喋啶 高血压 

分 类 号：R972.4[医药卫生—药品]