腺苷预适应对心脏的保护效应及机制探讨  

PROTECTIVE EFFECT OF ADENOSINE PRECONDITIONING ON MYOCARDIUM INJURED BY ISCHEMIA/REPERFUSION

作　　者：丁家望[1] 刘志华[1] 冯义柏[1,2] 卢永昕[1,2] 曾秋棠[1,2] 

机构地区：[1]三峡大学第一临床医学院,宜昌市中心人民医院心内科,湖北省宜昌市443003 [2]华中科技大学同济医学院附属协和医院心内科

出　　处：《中国心血管病研究》2004年第2期146-149,共4页Chinese Journal of Cardiovascular Research

摘　　要：目的 探讨腺苷预适应对心肌缺血/再灌注(I/R)损伤的保护作用。方法 通过建立家兔心脏I/R模型,观 察腺苷预适应对I/R心肌损伤的保护效应,以左心室功能恢复率、心肌梗死面积、心肌细胞肌酸激酶(CK)和乳酸脱 氢酶(LDH)漏出率的变化作为观察指标。结果 腺苷预适应组心功能恢复明显好于对照组(P均<0.01),CK、 LDH漏出率及心肌梗死面积均低于单纯I/R组(P均<0.01),这些心脏保护效应均被腺苷A1受体桔抗剂DPCPX 阻断。结论 腺苷通过其A1受体的激活介导了缺血预适应对I/R损伤的保护效应。Objective To assess protective effect on myocardium injured by ischemia/reperfusion (I/ R). Methods Protective effect of adenosine preconditioning on myocardium injured by I/R was observed. Cardiac function recovery, myocardial infarct size, lactate dehydrogenase(LDH) and creatine kinase(CK) leakage after I/R were measured in rabbit hearts. Results he recovery of postischemic heart function in adenosine preconditioning group was better than that of Control group (P < 0. 01), which was blocked by DPCPX(an adenosine selective receptor Al antagonist) . LDH and CK leakage in adenosine preconditioning group were lower than that of Contorl group I/R ( P < 0. 01), which was abolished by DPCPX. nfarct size in adenosine preconditioning group was smaller than that in control group(P<0.01), which was abrogated by DPCPX. Conclusion Adenosine preconditioning posseses myocardial protection injured by I/R. , which is mediated via adenosine selective receptor Al antagonist .

关 键 词：缺血预适应 心脏保护 心肌保护 腺苷受体 

分 类 号：R54[医药卫生—心血管疾病]