亲水性交联剂处理牛颈静脉的理化特征  

The Advantages of Bovine Jugular Vein Tanned with Hydrophilia Crosslinking Agent

作　　者：陈恩 丁文祥[2] 鲁亚男[2] 蒋祖明 俞晓青 邹文艳 

机构地区：[1]上海市先天性心脏病研究所,上海200127 [2]上海第二医科大学附属新华医院上海儿童医学中心,上海200127

出　　处：《生物医学工程学杂志》2004年第1期66-68,71,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目 ( 3 9870 2 0 7)

摘　　要：分别用 4 %的 EX- 313与 0 .5 %的戊二醛处理牛颈静脉带瓣胶原管道 ,所获的材料分别进行外观、扫描电镜与光镜检查 ;另外进行大鼠皮下埋植试验 ,生物力学的测试 ,所获的数据进行 t检验。EX- 313处理后的材料比戊二醛处理者质地更接近天然血管 ,结构间充满空隙 ,抗张强度与戊二醛处理者相当 ,抗钙化方面 EX- 313处理者明显优于戊二醛处理者。用亲水性交联剂 EX- 313处理的生物材料在抗钙化与顺应性方面比戊二醛更有优势 。The bovine jugular veins were divided into two groups and treated with 4% EX-313 and 0.5% glutaraldehyde respectively, and then they were examined with naked-eye, microscope and scanning electron microscope. Biomechnics test and dorsal implantation in rats were performed. The aquired data were processed and subjected to t-test. The EX-313 fixed material was more pliable than the glutaraldehyde treated material, and the former had higher anticalcification than the latter. In conclusion, the hydrophilia crosslinking agent EX-313 is superior to glutaraldehyde in treating biomaterials, and the bovine jugular vein tanned with EX-313 should be a promising material for repairing in cardiovascular surgery.

关 键 词：亲水性交联剂 牛 颈静脉 生物材料 

分 类 号：R318.08[医药卫生—生物医学工程]