血液净化对慢性肾功能衰竭患者全段甲状旁腺激素的影响  

Effect of blood purification on plasma levels of intact parathyroid hormone in patients with chronic renal failure

作　　者：刘俊[1] 刘志强[1] 陶惠琴[1] 

机构地区：[1]第一军医大学南方医院肾内科,广东广州510515

出　　处：《第一军医大学学报》2004年第2期234-235,共2页Journal of First Military Medical University

摘　　要：目的研究血液灌流和/或血液透析对慢性肾功能衰竭(CRF)患者全段甲状旁腺激素(iPTH)的影响。方法用放射免疫测定法检测40例规律血液透析患者治疗前后iPTH水平。结果血液灌流和/或血液透析后iPTH水平均降低,但血液灌流组降低幅度大于血液透析组(P=0.031)。结论血液灌流加血液透析能比单纯血液透析更有效地降低CRF患者iPTH水平。Objective To study the effects of hemoperfusion and/or hemodialysis on plasma levels of intact parathyroid hormone (iPTH) in patients with chronic renal failure (CRF). Methods A total of 40 uremic patients were randomly divided into two groups to receive hemoperfusion in combination with hemodialysis (HP+HD) or exclusive hemodialysis (HD), respectively. Plasma iPTH concentration was measured by means of radio immunoassay. Results After the blood purification procedures, the patients' plasma iPTH levels were reduced from 1 508.70±1 268.89 to 1 049.04±992.91 μg/ml (P<0.001) in HD group and from 1 600.70±1 151.15 to 745.47±785.02 μg/ml (P<0.001) in HP+HD group. Conclusion Blood purification with hemoperfusion plus hemodialysis may decrease plasma iPTH levels more efficiently than hemodialysis performed alone.

关 键 词：血液净化 慢性肾功能衰竭 甲状旁腺激素 血液灌流 血液透析 

分 类 号：R692.5[医药卫生—泌尿科学]