旋转填充床中反溶剂重结晶法制备超细硫酸沙丁胺醇实验研究  

Preparation of Particles of Ultra-fine Salbutamol Sulfate by Anti-Solvent Re-crystallization in a Rotating Packed Bed

作　　者：马静[1] 王玉红[1] 王丹梅 陈建峰[1] 甄崇礼 

机构地区：[1]北京化工大学教育部超重力工程研究中心,北京100029 [2]新加坡义安理工学院 [3]新加坡纳米材料科技有限公司

出　　处：《材料科学与工程学报》2004年第1期74-77,共4页Journal of Materials Science and Engineering

基　　金：国家自然基金(2 0 1 4 60 0 2 );国家"863"计划资助项目 (2 0 0 1AA2 1 80 1 6)

摘　　要：本文在旋转填充床中用反溶剂重结晶方法对硫酸沙丁胺醇原料药品进行了细化。研究了结晶温度、反溶剂与硫酸沙丁胺醇水溶液流量比、旋转填充床转速等操作参数对硫酸沙丁胺醇颗粒大小及收率的影响。实验结果表明 ,采用较低的结晶温度、较大流量比和较大旋转填充床转速可以得到粒度小于 5 0 0nm的硫酸沙丁胺醇颗粒。Particles of ultra-fine salbutamol sulfate were produced by anti-solvent re-crystallization in a rotating packed bed(RPB). The effects of operating factors such as the crystallization temperature, the ratio of flow rate of anti-solvent to salbutamol sulfate solution, and the rotating speed of RPB on the yield and particle size of products were investigated experimentally. The results show that particles of ultra-fine salbutamol sulfate can be produced in low crystallization temperature, high ratio of flow rate of anti-solvent to salbutamol sulfate solution and high rotating speed of RPB.

关 键 词：旋转填充床 反溶剂重结晶法 硫酸沙丁胺醇 药品制备 呼吸道疾病 

分 类 号：TQ463.23[化学工程—制药化工] R974[医药卫生—药品]