阿奇霉素中相关物质的研究  

Studies of Related Substances of Azithromycin

作　　者：姜建国[1] 张西茹[1] 吴如金[2] 杨梁[1] 

机构地区：[1]河北省药品检验所,石家庄050011 [2]中国药科大学药物分析教研室,南京210009

出　　处：《中国药科大学学报》2004年第1期43-46,共4页Journal of China Pharmaceutical University

摘　　要：目的 :研究阿奇霉素中的相关物质。方法 :运用色谱学和波谱学方法分离鉴定阿奇霉素中的相关物质。结果 :从阿奇霉素中分离得到 4个相关物质 ,鉴定了其中 2个主要相关物质的结构分别为 3′ 氮去甲基阿奇霉素和 12 脱氧阿奇霉素。结论 :4个相关物质均为首次从阿奇霉素粗品中分离得到的新化合物 ,但其中AIM:To separate and to identify relat ed impurit ies of azithromycinMETHOD: Chromatographic and spectroscopic m eth ods were used to isolate and to identify the related substances in azithromycin RESULT:There were four related impurities which were isolated fro m azithromyci n and two of them were identified as 3′-N-demethyl- azithromycin and 12 -deoxy-a zithromycinCONCLUSION:Two novel compounds,3′-N-demethy l azithrom ycin and 12-deoxy-azithromycin as related substances of azithromycin were isol ated and their structures were elucidated for the first time

关 键 词：阿奇霉素 相关物质 分离 鉴定 

分 类 号：R927[医药卫生—药学]