系统性红斑狼疮血清同型半胱氨酸检测的临床意义  

The clinical significance of serum homocysteine detection in systemic lupus erythematosus

作　　者：曾智杰[1] 刘敏[1] 王松子[1] 俞纯山[1] 

机构地区：[1]中山大学附属第一医院检验医学部,广州市510080

出　　处：《实用医学杂志》2004年第2期203-205,共3页The Journal of Practical Medicine

摘　　要：目的 :探讨血清同型半胱氨酸 (Hcy)检测对系统性红斑狼疮 (SLE)患者的临床意义。方法 :应用荧光偏振免疫分析法 (FPIA)测定 68例SLE患者和 40例正常人的血清Hcy水平 ,并与常用实验室指标ANA、抗ds DNA、抗DNP作比较。结果 :SLE患者血清Hcy水平为 ( 17 17± 4 0 5 ) μmol/L ,活动期SLE组血清Hcy水平为( 18 64± 3 63 ) μmol/L ,缓解期SLE组血清Hcy水平为 ( 16 45± 4 60 ) μmol/L ,分别与正常对照组的 ( 10 12± 3 15 )μmol/L相比较差异均有极显著性 (P <0 0 1) ,活动期与缓解期血清Hcy水平相比较差异有显著性 (P <0 0 5 ) ;SLE患者在ANA阳性组血清Hcy水平 ( 17 3 6± 4 0 3 ) μmol/L较ANA阴性组 ( 12 99± 1 94) μmol/L有极显著增高 (P <0 0 1) ;在抗ds DNA阳性组血清Hcy水平 ( 18 3 8± 3 60 ) μmol/L较阴性组 ( 16 2 9± 4 61) μmol/L差异有显著性 (P<0 0 5 ) ;抗DNP阳性组 ( 18 10± 3 0 4) μmol/L与阴性组 ( 16 2 8± 4 3 9) μmol/L血清Hcy水平比较差异有显著性 (P<0 0 5 )。结论 :血清Hcy水平在SLE患者中明显升高 。Objective To study the clinical significance of serum homocysteine (Hcy) in Systemic Lupus Erythematosus (SLE). Methods With fluorescence polarization immunoassay (FPIA), serum homocysteine were tested in 40 healthy individuals and 68 SLE cases, including 41 active SLE cases and 27 inactive SLE cases. Results Sera Hcy in the SLE(17.17±4.05 μmol/L) (mean±S) were significantly higher than those in control group(10.12±3.15 μmol/L)(P<0.01). The concentrations of Hcy had significant difference between the active SLE (18.64±3.63 μmol/L) and the inactive SLE(16.45±4.60 μmol/L)(P<0.05). Significant differences were found between the ANA-positive cases(17.36±4.03 μmol/L)and the ANA-negative cases (12.99±1.94 μmol/L), anti-dsDNA-positive cases(18.38±3.60 μmol/L) and anti-dsDNA-negative cases (16.29±4.61 μmol/L), anti-DNP-positive (18.10±3.04 μmol/L) cases and anti-DNP-negative (16.28±4.39 μmol/L) cases respectively. Conclusion Clinical significance was found in the detection of serum homocysteine in SLE patients.

关 键 词：系统性红斑狼疮 血清同型半胱氨酸 检测 荧光偏振免疫分析法 

分 类 号：R593.241[医药卫生—内科学]