哌拉西林钠/他唑巴坦钠治疗下呼吸道感染36例  

Therapy of Lower Respiratory Infection in 36 Patients with Piperacilin/Tazobactam

作　　者：陈锐[1] 袁封文 

机构地区：[1]山东省德州市人民医院药剂科,253014 [2]山东省德州军分区第一干休所,253014

出　　处：《医药导报》2004年第3期157-159,共3页Herald of Medicine

摘　　要：目的 :评价注射用哌拉西林钠 他唑巴坦钠治疗下呼吸道感染的临床疗效。方法 :下呼吸道感染患者 68例 ,分为治疗组 3 6例 ,给予注射用哌拉西林钠 他唑巴坦钠 4.5g ;对照组 3 2例 ,给予注射用头孢他啶 1.0g ,分别加入0 .9%氯化钠注射液 10 0mL中静脉滴注 ,q 8h ,疗程均为 7～ 14d。结果 :治疗组和对照组有效率分别为 94.4% ,90 .6% ;细菌清除率分别为 93 .1% ,84.6% (P <0 .0 5 ) ;不良反应发生率分别为 5 .6% ,3 .1%。结论 :哌拉西林钠 他唑巴坦钠对下呼吸道细菌感染临床疗效好且不良反应少 ,是一种高效。Objective:To determine the efficacy of piperacillin/tazobactam in the treatment of the lower respiratory infections. Methods:Sixty-eight patients with bacterial infections were divided divided into 2 groups. The treatment group (n=36) received 4.5 g piperacillin/tazobactam, and the control group (n=32) 1.0 g ceftazidime, all the drugs were given by i.v.infusion dissolving in 100 mL of sodium chloride injection, every 8 h for 7～14 d. Results:The effective rade effects for piperacillin/tazobactam were 94.4%, 93.1% and 5.3% respectively; and for ceftazidime were 90.6%, 84.6%, 3.1% respectively. Conclusions:Piperacillin/tazobactam is effective in the treatment of lower respiratory infections.

关 键 词：哌拉西林钠 他唑巴坦钠 头孢他啶 感染 下呼吸道 

分 类 号：R978.11[医药卫生—药品] R562[医药卫生—药学]