美金刚对急性毒鼠强中毒小鼠的实验治疗研究  

Therapeutic effect of memantine on acute tetramine poisoning in mice

作　　者：唐颖[1] 石峻岭[1] 顾锡安[1] 戴旭峰[1] 周志俊[1] 

机构地区：[1]复旦大学公共卫生学院,上海200032

出　　处：《中国工业医学杂志》2004年第1期1-3,共3页Chinese Journal of Industrial Medicine

摘　　要：目的　研究非竞争性NMDA受体拮抗剂美金刚对急性毒鼠强中毒小鼠的治疗作用。方法　根据正交实验设计原理 ,选用L9( 3 4)正交表 ,以存活时间、惊厥出现时间和抽搐出现时间为指标 ,测试美金刚对急性毒鼠强中毒小鼠的治疗效果。结果　美金刚明显延长急性毒鼠强中毒小鼠的存活时间 ,改善惊厥症状 ,延缓抽搐的出现 ,及早用药治疗效果好。结论　美金刚对急性毒鼠强中毒有治疗作用 ,建议可在临床上试用。但在正确掌握中毒指征及给药剂量方面 。Objective It is purposed to study therapeutic effect of memantine,a noncompetitive NMDA receptor antagonist,on acute tetramine poisoning in Kunming mice.Method Therapeutic effect of memantine on acute tetramine poisoning was evaluated by survival time and latency of onset of convulsion and muscular twitch in mice,based on L 9(3 4)orthogonal test table.Result Memantine could obviously prolong their survival time,delay their onset of convulsion and muscular twitch,and improve their symptoms in mice with acute tetramine poisoning.Better effect could be achieved with earlier use of memantine.Conclusion Memantine could effectively antagonize acute toxicity of tetramine in mice.It is suggested memantine be clinically used in treatment for acute tetramine poisoning on a trial basis.But,its indications and correct dose in clinical use should be studied further.

关 键 词：美金刚 急性毒鼠强中毒 小鼠 实验 治疗 非竞争性NMDA受体拮抗剂 

分 类 号：R595.4[医药卫生—内科学] R965[医药卫生—临床医学]