门脉高压大鼠胃粘膜前列腺素E_2含量的放免法测定  

RADIOIMMUNOASSAY OF GASTRIC MUCOSAL PROSTAGLANDIN E_2 IN PORTAL HYPERTENSIVE RATS WITH CIRRHOSIS

作　　者：穆毅[1] 申耀宗[1] 储一芳[1] 郑加麟[2] 张明志[3] 

机构地区：[1]徐州医学院肝胆外科研究室 [2]徐州医学院药理学教研室 [3]徐州医学院生物化学教研室

出　　处：《徐州医学院学报》1992年第4期299-301,共3页Acta Academiae Medicinae Xuzhou

摘　　要：用放射免疫分析法测定了肝硬变门脉高压大鼠的胃粘膜PGE_2含量,结果表明肝硬变门脉高压大鼠的含量显著低于正常大鼠的含量(91.86±14.11 VS 162.03±13.84pg/mg P<0.001)。讨论认为,PGE_2的减少使其对胃粘膜的保护作用削弱,是门脉高压时胃粘膜病变发生的因素之一。The gastric mucosal PGE2 content was measured by radioimmunoassay in portal hypertensive rats and in healthy rats. It was significantly lower in portal hypertensive rats than in healthy rats ( 91.86± 14.11 pg/mg vs 162.03 ±13.84 pg/mg, P<0.001). The results suggest that the decrease of PGE2 weakens the protective mechanism of gastric mucosa and hence whould be a relevant factor in the pathogenesis of gastric mucosal lesions in portal hypertension.

关 键 词：肝硬变 门脉高血压 前列腺素E2 

分 类 号：R657.340.2[医药卫生—外科学]