西藏茎直黄芪对山羊的毒性研究  

A STUDY ON TOXICITY OF ASTRAGALUS STRICTUS IN GOATS IN TIBET

作　　者：赵宝玉[1] 曹光荣[1] 段得贤[1] 李绍君[1] 鲁西科 王俊彪 

机构地区：[1]西北农业大学兽医系 [2]西藏自治区畜牧局

出　　处：《畜牧兽医学报》1992年第3期276-280,共5页ACTA VETERINARIA ET ZOOTECHNICA SINICA

摘　　要：本试验经瘤胃瘘管每天给6只山羊投股茎直黄芪粉(20g/kgB·W),并且给每只山羊茎直黄芪干草(200g/day),令其自由采食。第40～47天受试山羊出现以中枢神经系统机能紊乱为特征的中毒症状,表现为精神沉郁,摇头,目光呆滞,反应迟钝,步态蹒珊。继之,后肢无力,后躯麻痹,卧地不起。实验室检查发现,中毒羊血清AKP、GOT活性和BUN含量明显升高。病理组织学变化主要表现为神经细胞广泛空泡化。经分析茎直黄芪含苦马豆素,不含脂肪族硝基化合物,不是聚硒植物,从而证实苦马豆素可能是茎直黄芪的主要有毒成分。Certain dosage of pulverized astragalus strictus ( 20g/kgB. W ) isgiven to 6 goats per day via rumen fistula, supplemented with the dried plants ( 200g/day ) for each animal ad libitum. The goats appeared toxic signs characterized by CNS disorders: depression, shaking head, staring eyes, dull, ataxia on the day 40-47 of the experiment; at last hind limbs weakness, hind quarter paralysis, recumbency. Laboratory examination showed serum AKP,GOT and BUN increased significantly. Histopathological examination showed neuro visceral cytoplasma vacu-olation. Analysis of the plant showed that A. strictus, which is not a selenium accumlator and has no aliphatic nitro-toxins, contains indolizidine alkaloidswainsonine. It is considered that swainsonine may be main toxin compound of A. strictus.

关 键 词：茎直黄芪 苦马豆素 山羊 中毒 

分 类 号：S858.266.9[农业科学—临床兽医学]