急性冠状动脉综合征患者血管性假血友病因子、抗凝血酶Ⅲ及D-二聚体的变化  

Changes of von willebrand factor, antithrombin Ⅲ and D-dimer in patients with acute coronary syndrome

作　　者：陈曙光[1] 唐海沁[1] 

机构地区：[1]安徽医科大学附属医院干部病房心血管科,安徽合肥230022

出　　处：《疾病控制杂志》2003年第3期223-225,共3页Chinese Journal of Disease Control and Prevention

基　　金：安徽省卫生厅科学研究基金 (2 0 0 2 A0 36 )

摘　　要：目的　研究急性冠状动脉综合征 (ACS)患者血管性假血友病因子、抗凝血酶 及 D-二聚体改变特点并探讨其临床意义。方法　对 ACS组 (31例 )及对照组 (2 0例 )的血管性假血友病因子(VWF)、抗凝血酶 (AT- )和 D-二聚体 (D- dimer)进行检测和分析 ,同时测定血小板 (PL T)计数、血浆凝血酶原时间 (PT)、部分凝血活酶时间 (APTT)、凝血酶时间 (TT)、纤维蛋白原 (FIB)。结果　与正常对照组比较 ,ACS组的 VWF、D- dimer明显增高 (P <0 .0 5 ) ,AT- 明显降低 (P <0 .0 5 ) ,VWF与D- dimer之间相关无显著性 (r=0 .0 36 ,P>0 .0 5 )。结论　 ACS患者存在血管内皮损伤。Objective To study the clinical significance of changes of von willebrand factor, antithrombinⅢ and D dimer in patients with acute coronary syndrome. Methods Von willebrand factor (VWF), antithrombinⅢ(AT Ⅲ) and D dimer were measured in 31 cases of acute coronary syndrome (ACS) and 20 normal controls. Platelet (PLT), plasma prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB) were measured. Results Compared with the control subjects, the concentration of VWF and D dimer were significantly increased (P<0.05), AT Ⅲ was significantly lowered (P< 0.05 ) in the ACS group and the plasma level of VWF was not correlated with that of D dimer. Conclusions There were endothelial cell disturbance, increased coagulability and impairment of fibrinolysis in ACS.

关 键 词：急性冠状动脉综合征 血管性假血友病因子 抗凝血酶Ⅲ D-二聚体 ACS 流行病学 

分 类 号：R543.3[医药卫生—心血管疾病]