力学负荷对峰值骨量影响的初步研究  

Effects of mechanical load on peak bone mass

作　　者：杨定焯[1] 杨惠[2] 刘芳[2] 张倩[2] 王文志[2] 

机构地区：[1]四川大学华西第四医院,成都610041 [2]华西医科大学附属第三医院

出　　处：《中国骨质疏松杂志》2003年第2期124-127,共4页Chinese Journal of Osteoporosis

摘　　要：目的　人的运动器官含骨量的多少与外力有关。本实验研究了重力、肌力对骨量的影响。方法　排除了继发性骨质疏松 ,用DXA对男 56例、女 55例受试者测量全身骨量 ,收集BMC、BMD、体重、瘦体重指标。结果　发现全身体重和瘦体重与BMC呈密切相关 ,与BMD的相关较弱。女性的相关强于男性 ,男女相同体重配对后 ,男性的BMC、瘦体重、握力分别大于女性 3 5 %、2 7 8%、44 %。这可能是男性力学性能优于女性的重要原因 ,而且男性体重每大于女性 1kg其BMC较女性增加 0 0 2 0kg ;男性瘦体重每大于女性 1kg其BMC较女性增加 0 0 0 8kg;体重和肌力都是决定BMC的因素 ,体重可能是决定BMC的重要外力。结论　应该进一步研究骨质疏松诊断中如何发挥骨力学的优越性。Objective Bone mass content of motion organs i s associated with external force This study involved the effect of gravity and, m uscular strength on bone mass Methods 111 subjects (56 males , 55 females) with exclusion of secondary osteoporosis and bone diseases were ran d omly recraited during physical examination Their general bone mass were measur e d by DEXA and general and local BMD and BMD, lean body mass, and gripping streng th were recorded Results General body weight and lean body m a ss were closely correlated with BMD, but weakly with BMD The correlaion coeffi c ients in females were higher than those in males BMC, lean body mass and grip s trength in males were 3 5%, 27 8% and 44% higher than these in females respect iv ely This may be the important reason that bone mechanical property of males is better than that of females With every 1 kg body weight in males over that in females, the BMC in male was 0 020 kg over that in females With every 1 kg le an body mass in males over that in females, the BMC in males was 0 008 kg over t h at in females So we inferred that weight might be the important external force to determine BMC Conclusions Both weight and muscular strengt h are important factors for determining bone mineral content Application of bon e mechanical measurment to diagnosis of osteoporosis should be further studied

关 键 词：力学负荷 峰值骨量 骨强度 诊断 骨力学 

分 类 号：R336[医药卫生—人体生理学] R318.01[医药卫生—基础医学]