抗体工程研究进程及在控制病毒感染中的作用  

Research processing of genetic antibody and the function in viral infection controll

作　　者：段涛[1] 谷淑燕[1] 

机构地区：[1]中国疾病预防控制中心病毒病预防控制所,北京100052

出　　处：《生物技术通讯》2003年第6期531-534,共4页Letters in Biotechnology

摘　　要：多年来研究人员一直在寻求单克隆抗体在病毒性疾病中的临床应用。鼠源单克隆抗体可能会引发患者的免疫 反应,降低其疗效,故研究人员相继开发了嵌合抗体、改型抗体、噬菌体抗体及利用基因工程方法改造植物和动物产 生人源抗体以应用于临床治疗。抗体工程在控制多种病毒感染性疾病方面已经发挥了一定作用并将发挥重要作用。Researchers have sought therapeutic applications in viral disease for many years. However, human anti-mouse response raises serious problems in human patients, reducing their therapeutic efficacy. Antibodies produced through the use of humanized antibody, phage display systems and genetically modified plants and animals provide researchers alternative, these antibodies can be used in the controlling of viral disease and will play a key role in many fields.

关 键 词：病毒感染 抗体工程 控制 研究进程 单克隆抗体 

分 类 号：R392[医药卫生—免疫学] R373[医药卫生—基础医学]