前列地尔脂微球载体注射液治疗重度黄疸肝炎33例  

Efficacy of Lipo PGE_1 injection in treatment of 33 patients with severe icterohepatitis

作　　者：吴金国[1] 

机构地区：[1]温州医学院附属第三医院感染科,温州325200

出　　处：《中国新药杂志》2004年第1期70-72,共3页Chinese Journal of New Drugs

摘　　要：目的:探讨前列地尔脂微球载体注射液对重度黄疸肝炎的疗效。方法:将64例重度黄疸肝炎患者随机分为2组,治疗组33例,对照组31例,在促肝细胞生长素80mL静脉点滴的基础上,治疗组加用前列地尔脂微球载体注射液10mL,对照组加用茵栀黄注射液40mL,2组药物均溶于5％葡萄糖液500mL中静滴,qd,疗程为4周。结果:治疗组重度黄疸肝炎的有效率显著高于对照组(P<0.05),血清胆红素显著低于对照组(P<0.01),谷丙转氨酶(ALT)和血浆凝血致活素前体(PTA)均显著低于对照组(P<0.05)。结论:前列地尔脂微球载体注射液对重度黄疸肝炎有较满意的疗效。Objective:To study the efficacy of Lipo PGEi injection in treatment of icterohepati-tis. Methods: 64 patients with severe icterohepatitis were randomly divided to receive once daily HGPF (hepatocyte growth-promoting factor) plus Lipo PGE1 injection 10mL (n=33) or once daily HGPF plus Yinzhihuang injection 40mL( n=31) for 4 weeks. Drugs in both groups were given by infusion after dissolved in 500mL of glucose injection. Results:The effective rate in the treatment group was significantly higher than those of the control group (P<0.05) and the serum bilirubin,alanine transami-nase (ALT) and plasma thromboplastin antecedent (PTA) value in the treatment group were significantly lower than those of the control group (P<0.01 ,P<0.05). Conclusion:Lipo PGE1 injection is effective in treatment of severe icterohepatitis.

关 键 词：前列地尔脂微球载体注射液 重度黄疸肝炎 血清胆红素 谷丙转氨酶 血浆凝血致活素前体 

分 类 号：R975.5[医药卫生—药品] R442.4[医药卫生—药学]