[^(99)Tc^m(Co)_3(CHI)_3]^+的制备及其生物分布  

Preparation and Biodistribution of [^(99)Tc^m(Co)_3(CHI)_3]^+

作　　者：张现忠[1] 温海涛[1] 王学斌[1] 

机构地区：[1]北京师范大学化学系,北京100875

出　　处：《同位素》2003年第3期147-150,共4页Journal of Isotopes

基　　金：北京师范大学青年科学基金资助项目(理科)(107195)

摘　　要：以99TcmO4-淋洗液为起始物,在低压条件下制备了中间体[99Tcm(CO)3(H2O)3]+,并通过配体交换反应得到放化纯度大于90％的[99Tcm(CO)3(CHI)3]+配合物。该配合物在室温下放置6 h以上放化纯度无明显变化。在正常昆明小鼠体内的生物分布实验结果表明,[99Tcm(CO)3(CHI)3]+具有一定的心肌摄取,且滞留也相当好;在注射后5 min和60 min时的心肌摄取值分别为(13.59±2.12)％ID/g和(13.87±1.54)％ID/g。尽管该配合物的肝和肺本底摄取较高,但是与99TcmN—CHI和99Tcm-CHI相比,羰基锝中心核的引入还是大大改善了配合物用于心肌显像的性能,为发展新的心肌显像剂提供了一种新思路。Starting from [99TcmO4]- and at 0.1 MPa CO pressure conditions, the important starting material [99Tcm(CO)3(H2O3]+ is synthesized. By ligand exchanging of this starting material with isonitrile ligand CHI (Cyclohexylisonitrile), the complex [99Tcm(CO)3(CHI)3]+ is prepared. Its ra-diochemical purity is more than 90%, and it is stable over 6 h at room temperature. The biodistri-bution of this new complex in normal mice indicates that it has some myocardial uptake and maintained well in it, the values of heart uptake at 5 min and 60 min post-injection are (13. 59±2.12)% ID/g and (13. 87±1.54)%ID/g, respectively. Unfortunately the uptakes of non-targets, such as liver and lung, are also quite high. Compared with 99TcmN-CHI and 99Tcm-CHI, the tricarbonyl complex [99Tcm(CO)3(CHI)3]+ has the most suitable properties for myocardial imaging.

关 键 词：[^-99Tc^m(CO)3(CHI)3]^+ 制备方法 生物分布 异腈配体环己基异腈 CHI 心肌显像剂 

分 类 号：R81[医药卫生—放射医学]