川芎嗪预防急性缺血性肾衰竭的实验研究  

Experimental Study on Tetramethylpyrazines in Preventing Ischemic Acute Renal Failure

作　　者：潘龙[1] 李小会[1] 曹彩霞[1] 贺琲珺[2] 

机构地区：[1]陕西中医学院附属医院肾内科,西安712083 [2]陕西中医学院

出　　处：《中国中西医结合肾病杂志》2004年第2期78-79,共2页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：陕西省教育厅基金资助项目 (No .0 2JK188)

摘　　要：目的 :探讨川芎嗪对大鼠急性缺血性肾衰竭 (IARF)的保护作用及其可能的作用机制。方法 :采用同时钳夹双侧肾动脉 4 5min ,再灌注 2 4h建立大鼠IARF的动物模型 ,设立假手术组、造模组及川芎嗪预防组。观察各组大鼠血肌酐 (Scr)、血清尿素氮 (BUN)、血清一氧化氮 (NO)、血清内皮素 (ET)及肾脏病理的变化。结果 :与造模组比较 ,川芎嗪预防组的Scr、BUN及ET水平明显降低 (P <0 .0 5 ) ,血清NO明显升高 (P <0 .0 5 )。结论 :川芎嗪能减轻IARF的肾脏损害 ,对肾脏有保护作用 。Objective:To study the protective effects and mechanism of tetramethylpyrazines(TMP) in ischemic acute renal failure(IARF).Methods:Ischemic acute renal failure model was established by bilateral clipping of renal arteries for 45min and reperfusion for 24 hours. Rats were assigned into sham, model and TMP-treated groups. Serum creatinine(Scr), blood urea nitrogen(BUN), nitrogen monoxide(NO), endothelin(ET) and renal pathology were analyzed. Results:Scr, BUN and ET were significantly lower in TMP-treated group than those of model group(P<0.05) while NO was significantly higher in TMP-treated group than that of model group(P<0.05).Conclusion:The protective effects TMP in reducing renal lesions induced by IARF may be associated with regulation of ET secretion and serum NO concentration.

关 键 词：川芎嗪 预防 急性缺血性肾衰竭 实验研究 

分 类 号：R285.5[医药卫生—中药学]