孤啡肽与子宫内膜异位不孕的相关研究  

Study on the relationship between orphanin and infertility with endometriosis

作　　者：胡电[1] 古航[1] 金志军[1] 刘彦[1] 熊英[1] 章青[1] 

机构地区：[1]第二军医大学长征医院妇产科,上海200003

出　　处：《中国优生与遗传杂志》2004年第1期85-85,88,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的　探讨子宫内膜异位症 (内异症 )不孕患者血孤啡肽含量的变化及对生殖内分泌的影响。方法　采用放射免疫法测定 2 1例内异症不孕妇女 (不孕组 )、2 3例单纯输卵管阻塞不孕妇女 (对照组 )及 30例健康妇女 (正常组 )血孤啡肽及卵泡刺激素 (FSH)、黄体生成素 (LH)的含量。结果　 (1)不孕组妇女血孤啡肽及FSH、LH的含量分别为 (2 9.6 1± 6 .33)ng.L-1、(2 .0 3± 0 .32 )IU .L-1及 (6 .4 3± 1.89)IU .L-1,对照组妇女血孤啡肽及FSH、LH的含量分别为 (10 .18± 3.6 4 )ng .L-1、(4 .0 5± 05 1)IU .L-1及 (15 .0 5± 4 .2 6 )IU .L-1,正常组分别为 (11.35± 3.71)ng .L-1、(3.82± 0 .4 6 )IU .L-1及 (12 .6 3± 3.18)IU .L-1。 (2 )内异症不孕组妇女血孤啡肽水平显著高于对照组及正常组 (P<0 .0 1及P<0 .0 5 )。 (3)不孕组妇女血FSH、LH的含量显著低于对照组及正常组 (P <0 .0 1及P<0 .0 5 )。 (4 )内异症不孕妇女血孤啡肽及FSH、LH水平显著负相关 (P <0 .0 5 )。结论　孤啡肽与子宫内膜异位不孕的发生发展密切相关 ,其机理可能与抑制FSH及LH的分泌有关。Objective: To evaluate the relationship of orphanin (OFQ) and reproductive hormone(FSH and LH) in the patients of infertility with endometriosis(EMT). Methods: 21 patients of EMT with infertility (infertility group), 23 infertile women without EMT (control group) and 30 health women(normal group) were studied. The concentrations of plasma OFQ and serum FSH and LH were measured by radioimmunoassay. Results: The levels of OFQ , FSH and LH in infertility group were (29.61±6.33)ng.L -1,(2.03±0.32)IU.L -1 and (6.43±1.89) IU.L -1 respectively, the levels of OFQ, FSH and LH in control group were (10.18±3.64)ng.L -1,(4.05±0 51)IU.L -1 and(15.05±4.26)IU.L -1 respectively, in normal group, the levels were (11.35±3.71)ng.L -1 , (3.82±0.46)IU.L -1 and(12.63±3.18)IU.L -1 respectively .The level of plasma OFQ in infertility and pregnancy group were significantly higher than that in the control group and normal group(P<0.01), the levels of FSH and LH in infertility group decreased significantly when compared with the control group and normal group (P<0.01 and P<0.05). Conclusions: Infertility with endometriosis was associated with OFQ, the changes of OFQ levels may play an important role on infertility with endometriosis,it could effectively inhibit the secretion of FSH and LH.

关 键 词：孤啡肽 卵泡刺激素 黄体生成素 不孕 子宫内膜异位症 

分 类 号：R711.6[医药卫生—妇产科学]