新生儿感染性疾病IL-6、IL-8和TNFα的研究  

The study of interleukin-6 interleukin-8 and tumor necrosis factor alpha in newborn with infection

作　　者：冯小三[1] 黄绍敏 

机构地区：[1]暨南大学附属第三医院儿科,珠海519000 [2]华中科技大学附属协和医院

出　　处：《中国优生与遗传杂志》2004年第1期93-94,117,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的　分析比较新生儿感染性疾病 (败血症与一般感染 )血浆中细胞因子直接及诱生水平的变化特征。方法　采用双抗体夹心酶联免疫吸附实验法 (ELISA)测定白细胞介素 6 (IL - 6 )、白细胞介素 8(IL - 8)和肿瘤坏死因子α(TNFα)的水平。结果　入院时败血症、一般感染患儿血浆IL - 6、IL - 8、TNFα直接水平显著高于各自恢复期 (P <0 .0 5 ) ,败血症患儿三者极显著高于健康对照组 (P <0 .0 1) ,一般感染患儿三者显著高于健康对照组 (P <0 .0 5 ) .两组恢复期三者与健康对照组无显著性差异 (P >0 .0 5 ) ,入院时败血症三者显著高于一般感染患儿 (P <0 .0 5 )。结论　新生儿血浆中高水平的IL - 6、IL - 8和TNFα提示机体存在感染 ,可做为早期诊断的灵敏指标 ,并与感染轻重程度有关 ,还可做为判断疗效的指标。Objective: To study the plasma levels of cytokines in newborn with sepsis and infection. Methods: Cytokines were measured by sanwich enzyme-linked immunosorbent assay. Results: The plasma IL-6,IL-8 and TNFα levels in newborn with sepsis and infection had significantly higher at the onset of disease than those at the recovery of disease (P<0.05).At onset ,three cytokines in newborn with sepsis and infection had significantly higher than those of control group(P<0.01,P<0.05).At recovery ,no difference of three cytokines were found among newborn with sepsis ,infection and control group(P>0.05).At onset ,three cytokines of newborn with sepsis had significantly higher than those of infection(P<0.05).Conclusions: The high levels of IL-6,IL-8 and TNFα in newborn plasma indicated infection, and had correlation with degreety of infection .Inflammatory cytokines might be sensitive markers of diagnosis and return of neonatal infection.

关 键 词：新生儿 白细胞介素6 白细胞介素8 肿瘤坏死因子Α 感染 

分 类 号：R722.13[医药卫生—儿科]