粉防己碱治疗大鼠移植动脉硬化的实验研究  

Experimental study of tetrandrine for treatment of transplant arteriosclerosis in rats

作　　者：徐振萍[1] 刘忠民 沈文律 关兆杰 

机构地区：[1]泰安市中心医院,山东泰安271000 [2]广东省深圳龙岗区人民医院外一科,广东深圳市518172

出　　处：《心血管康复医学杂志》2004年第1期43-44,共2页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨粉防已碱(Tet)对大鼠移植动脉硬化的治疗作用。方法:雄性SD和Wistar大鼠各10只,分别作为供、受体。腹主动脉移植后Wistar大鼠随机分为A组(Tet 20mg/kg·d治疗8周)、B组(对照组),术后8周切取植入的腹主动脉行光镜检查。结果:Tet治疗组和未治疗组术后均有动脉内膜增生,较之正常对照组差异非常显著(P<0.01),但Tet治疗组的内膜增生较未治疗组明显降低(P<0.01),其动脉外膜的细胞浸润减少。结论:20mg/kg的Tet可以减轻但不能防止移植动脉硬化的发生。Objective: To evaluate the efficacy of tetrandrine (Tet) for treatment of transplant arteriosclerosis in a rat abdominal aortic allograft model. Methods: Male SD aortic allografts were transplanted to wistar recipients. The recipient rats were grouped randomly into group A (Tet at dose of 20 mg/kg.d for 8 wk) and B (untreated control allografts). Histological changes were monitored after 8 wk of operation. Results: There were significantly intima proliferation both in Tet-treated allografts and untreated control allografts (P<0. 01) compared with normal controp group, but the intima proliferation in Tet-treated allografts significantly decreased (P<0. 01) compared with that in untreated control allografts, and the adventitial infiltration in the aortic walls of Tet-treated allografts' was also reduced. C5nclusion: At a dose 20 mg/kg.Tet can attenuate but not prevent the development of the chronic rejection.

关 键 词：粉防己碱 治疗 大鼠 移植动脉硬化 TET 移植器官 

分 类 号：R543.5[医药卫生—心血管疾病]