川芎嗪对糖尿病大鼠视网膜组织型纤溶酶原激活物含量的影响  

Effect of ligustrazine on tissue-type plasminogen activator in the retina of rats with diabetes mellitus

作　　者：陈少强[1] 黄焱[1] 杨瑞铭[1] 张更[1] 陈瑞华[1] 

机构地区：[1]福建医科大学解剖学与组织胚胎学系,福州350004

出　　处：《中国中医眼科杂志》2004年第1期2-4,共3页China Journal of Chinese Ophthalmology

基　　金：福建省自然科学基金资助课题(C 981 0 0 34 )

摘　　要：目的　探讨糖尿病视网膜病变 (diabeticretinopathy,DR)的发病机制及川芎嗪治疗糖尿病视网膜病变的机制。方法　将SD大鼠随机分成正常对照组、糖尿病组和糖尿病川芎嗪治疗组。后两组大鼠一次性腹腔注射链脲佐菌素 (streptozotocin ,STZ)诱发糖尿病模型 ,于第 30天和第 90天测定各组大鼠视网膜组织型纤溶酶原激活物 (tissue-typeplasminogenactivator,TPA)的含量。结果　糖尿病组大鼠视网膜TPA含量高于正常对照组。治疗组大鼠视网膜TPA含量低于糖尿病组。结论　DR的发生与视网膜TPA含量升高有关 。OBJECTIVETo explore the mechanism of diabetic re ti nopathy(DR) for development and protective effect of ligustrazine on diabetic re tinopathy METHODSHealthy adult SD rats were divided into cont rol group,diabetic group and treated diabetic group with ligustrazine random Diabetes mellitus were induced by injection of streptozotocin into celiac only o ne time in the diabetic group and diabetic group treated with ligustrazine The content of tissue-type plasminogen activator (TPA) were quantified at 30 days a nd 90 days in the retina of all rats RESULTSThe content of TP A was higher in the diabetic group than control group The content of TPA in th e retina was lower of in the treated rats with diabetes mellitus than in the dia betic group CONCLUSIONDevelopment of diabetic retinopathy is related to the increasing content of TPA Ligustrazine could be receded conten t of TPA, and it is effect on prevention and cure of diabetic retinopathy

关 键 词：川芎嗪 糖尿病 视网膜病变 组织型纤溶酶原激活物 大鼠 含量 

分 类 号：R285.5[医药卫生—中药学] R774.1[医药卫生—中医学]