SEN病毒感染与慢性肝病的关系  

The Relationship Between SEN Virus Infection and Chronic Liver Disease

作　　者：朱峰[1] 蔡晓东[1] 钱家鸣[1] 费贵军[1] 杨晓鸣[1] 

机构地区：[1]中国医学科学院中国协和医科大学协和医院消化科,北京100730

出　　处：《临床消化病杂志》2004年第1期3-5,37,共4页Chinese Journal of Clinical Gastroenterology

摘　　要：目的 :揭示SEN病毒 (SEN V)感染与慢性肝病之间的关系。方法 :使用SEN VPCR引物 ,从 50例健康志愿者及 2 60例慢性肝病患者 (包括 45例不明原因肝炎、1 2 5例肝硬化和 90例原发性肝细胞肝癌患者 )血清中检测SEN VDNA ,每份DNA样本均取自lml血清。记录各组患者的临床特点 ,并分析其与SEN V感染的关系。结果 :SEN VDNA在健康志愿者、不明原因肝炎患者、肝硬化患者和原发性肝细胞肝癌患者中阳性检出率分别为 1 6 .0 0 %、2 2 .2 2 %、36 .80 %和 2 1 .1 1 % ,仅肝硬化组与健康对照组有显著差异 (P <0 .0 5)。肝硬化组中 ,丙型肝炎病毒 (HCV)感染、HCV和乙型肝炎病毒 (HBV)共感染及不明原因的肝硬化患者SEN V感染率分别为 63 .64 %、62 .50 %和 54 .55 % ,均与对照组有显著差异 (P <0 .0 5)。所有 2 60例慢性肝病患者中 ,共 75例SEN V阳性 ,感染率达 2 8.85 % ,与对照组相比有显著差异 (P <0 .0 5)。SEN V在HCV感染中阳性率为 43 .75 % ,与对照组相比有显著差异 (P <0 .0 5)。在各组患者中 ,SEN V感染与否同患者的临床特点无相关关系。SEN V感染与输血亦无显著关联。结论 :SEN V较其它肝炎病毒在健康人群中的检出率高。在肝硬化患者 ,特别是丙型肝炎肝硬化患者中检出率较高。SENObjective: To investigate the relationship between SEN virus (SEN V)infection and chronic liver diseases. Methods: 50 healthy blood donors were selected as healthy control group and 260 patients with chronic liver diseases (CLD) including 45 for cryptogenic hepatitis, 125 for liver cirrhosis and 90 for hepatocellular carcinoma (HCC) were chosen randomly as patient groups. Serum DNA were extracted and PCR with SEN V specific primers (common primer) were conducted. DNA sequence check were also carried out to verify the positive PCR results. Statistical analysis were done with SPSS software. Results: The prevalence of SEN V in healthy controls, cryptogenic hepatitis patients, cirrhosis patients and HCC patients are 16.00%,22.22%,36.80% and 21.11%, respectively, with significant difference between the prevalence in the cirrhosis group and the control group (P<0.05) . In cirrhosis group, the prevalence of SEN V in hepatitis C virus (HCV) infected patients, HCV and hepatits B virus (HBV) coinfected patients, cryptogenic cirrohsis patients are 63.64%,62.50% and 54.55%, respectively, with significant difference compared with the control group (P<0.05). In all 260 CLD patients, 75 were shown SEN V DNA positive, with significant difference compared with the control group (P<0.05).The prevalence of SEN V in all HCV infected patients is 43.75%,with significant difference, compared with the control group (P<0.05). No significant correlation between SEN V infection and clinical indices including history of transfusion has been observed in any of the three patient groups. Conclusion: Compared to other hepatitis viruses, SEN V has relatively high prevalence in the general population. The prevalence in cirrhosis patients, especially in HCV infected cirrhosis patients are significantly higher than that of the healthy subjects that SEN V might have the similar transmiting route as HCV.

关 键 词：SEN病毒 不明原因肝炎 肝硬化 原发性肝细胞肝癌 

分 类 号：R512.6[医药卫生—内科学]