重型肝炎患者血清血管内皮细胞生长因子的含量及其临床意义  

Concentration and Clinical Significance of Vascular Endothelial Growth Factor in Serum of Patients with Severe Hepatitis

作　　者：翁志宏[1] 李淑莉[1] 蔡淑清[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院传染科,武汉430022

出　　处：《临床消化病杂志》2004年第1期8-9,共2页Chinese Journal of Clinical Gastroenterology

摘　　要：目的 :研究重型肝炎患者血清血管内皮细胞生长因子 (VEGF)的含量与重型肝炎预后的关系。方法 :采用ELISA定量检测55例重型肝炎患者 (其中急性重型肝炎 2例 ,亚急性重型肝炎 9例 ,慢性重型肝炎 44例 )及健康体检者血清VEGF含量。结果 :正常对照组、重型肝炎患者存活组、死亡组血清VEGF含量分别为 :44.73± 1 4 .71pg/ml,80 .48± 1 0 .47pg/ml,37.99± 1 2 .70pg/ml。提示重型肝炎患者存活组血清VEGF水平与正常对照组相比显著升高 (P <0 .0 5) ,死亡组略降低但无统计学意义 (P >0 .0 5)。结论 :(1 )VEGF与肝细胞再生密切相关 ;(2 )Objective: To study the relationship between the outcome of the severe hepatitis (SH) and the concentration of vascular endothelial growth factor (VEGF) in serum of patient with SH. Methods: Quantitative determination of serum VEGF with enzyme-linked immunosorbent assay (ELISA) was performed on 55 cases of patients with severe hepatitis (which including 2 cases of acute SH, 9 cases of subacute SH and 44 cases of chronic SH) and 10 cases of normal. Results: The concentration of serum VEGF in normal, the survivors of the SH and the nonsurvivors of the SH were 44.73±14.71 pg/ml , 80.48±10.47 pg/ml, 37.99±12.70 pg/ml, respectively. These suggested that the serum VEGF levels in survivors of SH were significantly increased than normal (P<0.05), but not in the nonsurvivors (P<0.05). Conclusion: (1) VEGF is associated with hepatocyte regeneration; (2) Determining the concentration of serum VEGF successively can predict the outcome of severe hepatitis.

关 键 词：重型肝炎 血管内皮细胞生长因子 

分 类 号：R512.6[医药卫生—内科学]