2-羧甲氧基苯甲醛苯甲酰腙及其配合物抑菌活性的构效关系  

Relationship of structure and bacteriostasis of 2-(carboxymethoxyl) be nzaldehyde benzoyl hydrazone or their complexes

作　　者：马兴铭[1] 雒艳萍[1] 麻宝成[2] 杨汝栋[2] 

机构地区：[1]兰州医学院基础医学院免疫学教研室,兰州730000 [2]甘肃兰州大学化学化工学院

出　　处：《中国临床药理学与治疗学》2004年第2期201-203,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的 :研究 2 羧甲氧基苯甲醛苯甲酰腙及其配合物的抑菌活性。方法 :合成配体 2 羧甲氧基苯甲醛苯甲酰腙及其配合物 ,采用K B法检测其对金黄色葡萄球菌、大肠埃希菌和枯草芽胞杆菌的生长抑制作用。结果 :配体 2 羧甲氧基苯甲醛苯甲酰腙仅抑制金黄色葡萄球菌的生长 ,其配合物能抑制金黄色葡萄球菌、大肠埃希菌和枯草芽胞杆菌的生长 ,形成抑菌环 ,尤其Cu配合物形成抑菌环直径最大。结论 :2 羧甲氧基苯甲醛苯甲酰腙与金属、稀土形成的配合物均有一定的抑菌作用 。AIM: To study ba cteriostasis activities of ligand (2-(carboxymethoxyl) benzaldehyde benzoyl hyd razone (H 2L)) and their complexes. METHODS: Ligand H 2L and t heir complexes were synthesized. The bacteriostasis activities of H 2L and thei r complexes in vitro were tested with K-B method. RESUL TS: 2-(carboxymethoxyl) benzaldehyde benzoyl hydrazone only showed bact eriostasis activities on Staphyloccus aureus and their complexes had dramatic bacteriostasis activity on Staphylococcus aureus, Escherichia coli, and Bacillus subtilis. Bacteri ostasis ring diameter of Cu-complex was largest. CONCLUSION: L igand H 2L complexes have bacteriostasis activities in vitro. B acteriostasis activities of Cu-complex are strongest among the complexes.

关 键 词：腙类化合物 配体 配合物 体外抑菌 K-B法 

分 类 号：R965[医药卫生—药理学] R37[医药卫生—药学]