白介素-4受体基因多态性与哮喘发病关系的研究  

A Study on the Relationship between Interleukin-4 Receptor Polymorphism and Asthma

作　　者：杨青[1] 邹叶青[1] 况九龙[1] 

机构地区：[1]江西医学院第二附属医院呼吸内科,江西南昌330006

出　　处：《江西医学院学报》2004年第1期37-39,共3页Acta Academiae Medicinae Jiangxi

摘　　要：目的　探讨白介素 4受体 (IL 4R)基因多态性 (Ile5 0Val)与哮喘发病之间的关系。方法　采用聚合酶链反应 -限制性片段长度多态性分析法 (PCR RFLP)检测 34例哮喘患者、2 9例健康人IL 4R基因型。结果　哮喘组与健康对照组三种基因型 (Ile/Ile、Val/Ile、Val/Val)在分布上无显著差异 (P >0 .0 5 ) ,哮喘组Ile5 0基因型出现的频率为 0 .4 85 ,对照组为 0 .5 5 2 ,两组比较无显著性差异 (P >0 .0 5 )。结论　IL 4受体基因多态性 (Ile5 0Val)可能与哮喘发病无关。Objective The objective of the study was to evaluate the possible relationship between IL-4 receptor polymorphism(Ile50Val)and asthma.Methods The study was conducted in two different populations: asthmatics(n=34)and healthy people(n=29).The IL-4R Ile50Val polymorphism was genotyped by polymerase chain recation-restriction fragment length polymorphism analysis(PCR-RFLP).Results There was no significant difference in the distributions of the genotypes(Ile/Ile、Val/Ile、Val/Val)between the asthmatic group and the control group(P>0.05).Ile50 frequency was 0.485 in asthmatic group and 0.552 in control group.There was no significant difference in Ile50 frequency between the two groups(P>0.05).Conclusion Our data suggest that IL-4R polymorphism(Ile50Val)is not associated with the development of asthma.

关 键 词：哮喘 白介素-4受体 多态性 

分 类 号：R562.25[医药卫生—呼吸系统]