新生儿窒息后血浆IL-6、IGF-1水平的变化及其与脑损伤的关系  

Relationship of interleukin-6 and insulin-like growth factor-1 serum levels with brain damage in neonatal asphyxia.

作　　者：周毅虹[1] 唐兰芬[1] 敖当[1] 苏赞彩[1] 揭育丽 

机构地区：[1]广东医学院附属医院儿科,广东湛江524001

出　　处：《广东医学院学报》2004年第1期16-17,共2页Journal of Guangdong Medical College

摘　　要：目的 :探讨外周血白细胞介素 6 (IL 6 )与胰岛素样生长因子 1(IGF 1)在新生儿窒息中的变化及其与脑损伤的关系。方法 :采用放射免疫法检测 5 0例窒息新生儿及 2 0例正常新生儿生后第 1、3、7天血清IL 6与IGF 1水平变化 ,并分析其与窒息后脑损伤的关系。结果 :窒息新生儿生后 3d内血清IL 6水平显著降低 ,与对照组比较差异有统计学意义 (P <0 .0 1) ,生后第 7天接近正常对照组水平 ,差异无统计学意义 (P >0 .0 5 ) ;而IGF 1生后 1周内均明显高于正常对照组水平 ,差异有统计学意义 (P <0 .0 1) ;头颅CT显示有脑损伤组IL 6明显低于CT正常组 ,IGF 1明显高于CT正常组 ,差异有统计学意义 (P均 <0 .0 5 ) ,IGF 1与IL 6呈明显负相关 (r= 0 .6 38,P <0 .0 1)。结论 :窒息新生儿外周血IL 6水平明显降低 ,IGF 1水平明显增高 ,它们可能参与了新生儿窒息后脑损伤的病理生理过程。Objective:To study the changes of interleukin-6(IL-6)and insulin-like growth factor-1(IGF-1) levels and their relation to brain damage in neonatal asphyxia.Methods:Serum concentrations of IL-6 and IGF-1 in 50 newborns with asphyxia and 20 normal neonates were detected by radioimmunoassay on day 1,3,and 7 after parturition.Results:Compared with controls,IL-6 level decreased obviously in asphyxiated newborns in 3 days after parturition (P<0.01),but it approached normal level on day 7(P>0.05).IGF-1 content in asphyxiated newborns was superior to that in controls in a week after parturition (P<0.01).IL-6 level in neonates with brain damage was significantly lower than that without brain damage (P<0.05),but IGF-1 content was on the contrary (P<0.05).There was a negative correlation between IGF-1 and IL-6(r=-0.638,P<0.01).Conclusion:Asphyxiated newborns have an increase of IL-6 level and a decrease of IGF-1 content.Both cytokines could be involved in the pathophysiology of neonatal asphyxia.

关 键 词：窒息 新生儿 脑损伤 白细胞介素-6 胰岛素样生长因子-1 

分 类 号：R721.12[医药卫生—儿科]