骨骼肌中存在CD1a^+细胞  

The existence of CD1a^+ cells in the skeletal muscle

作　　者：徐长福[1] 任淑婷[1] 于琳华[1] 李恒力[1] 莫立平[1] 成少利[1] 王晓利[2] 

机构地区：[1]西安交通大学医学院病理学教研室,陕西西安710061 [2]西安交通大学第一医院老年内科,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2004年第1期30-32,共3页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家自然科学基金资助(No .30 370 544 );陕西省自然科学基金资助(No .2 0 0 2C2 33)

摘　　要：目的　研究骨骼肌中CD1a+ 细胞的形态、分布及功能。方法　 4例人骨骼肌样本采用CD1a抗体进行免疫组织化学染色 ,光镜观察。结果　骨骼肌纤维之间、肌束膜和肌外膜的血管壁、神经纤维、脂肪组织中的CD1a+ 细胞呈带状、灶状或散在分布。CD1a+ 细胞大小不等 ,形态多样 ,常有突起。突起粗细、长短、多少不等 ,其突起可与周围或远处的CD1a+ 细胞或突起相连 ;骨骼肌纤维之间的CD1a+ 细胞也可与肌膜紧密相连。结论　骨骼肌纤维之间的CD1a+ 细胞可能是肌卫星细胞的某一分化阶段 ;骨骼肌中各种组织内的CD1a+ 细胞也可能是相应组织成熟细胞的前体状态 ,并参与相应组织结构的形成和维持。Objective To investigate the morphology, distribu tion and significance of CD1a + cells in skeletal muscles. Methods Four samples of human skeletal muscles were lab eled by CD1a antibody with immunohistochemistry method, and then were observed u nder microscope. Results CD1a + cells at focal or scattering or band-like distribution could be seen in skeletal muscle tissue s including between skeletal muscular fibers, and between smooth muscle cells on the blood vessel wall, within nerve fiber, and fatty tissue and stroma in perim ysium and epimysium. CD1a + cells differed in size and shape, and usually w ith processes. Their processes were different in diameter, number and length, an d were connected with adjacent or distant CD1a + cells or processes; CDa + cells between skeletal muscular fibers might be connected with skeletal mu scular fiber tightly. Conclusion CD1a + cells between skeletal muscular fibers may be the certain phase of muscle satellite cell; CD1a + cells at different tissues in skeletal muscle may be the precursors of t he corresponding tissue mature cells, and may participate in maintaining the str ucture and function of corresponding tissues in skeletal muscle.

关 键 词：骨骼肌 CDla^+细胞 肌卫星细胞 树突状细胞 细胞形态 细胞分布 细胞功能 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]