一种具有微观仿生结构的定制化下颌骨植入体  

A NEW CUSTOMIZED MANDIBLE IMPLANTWITH BIONIC MICRO-STRUCTURE

作　　者：刘亚雄[1] 王珏[1] 卢秉恒[1] 李涤尘[1] 

机构地区：[1]西安交通大学,西安710049

出　　处：《中国生物医学工程学报》2004年第1期21-24,20,共5页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目 ( 5 9975 0 74);国家自然科学基金重点资助项目 ( 5 0 2 3 5 0 2 0)

摘　　要：为了使下颌骨人工植入体具有定制化的外形 ,并使其具有一定的生物活性及与人骨内部哈弗氏管和福克曼管类似的三维微观通道 ,提出了利用快速原型制造仿生下颌骨替代物的方法。该方法首先利用快速原型技术快速准确地制作出与人骨形状相匹配的人工植入体 (模型 )及内部三维仿生网架 ,而后运用铸钛技术完成植入体钛框架的最终成型 ,钛网内的三维仿生网架被复合有骨形态发生蛋白的磷酸钙骨水泥所包绕。该项研究结果不仅利用快速原型制作出仿生下颌骨人工植入体 ,还成功地投入临床应用。结论 :虽然仅以下颌骨为例 ,但快速原型适宜于所有仿生人工植入体的定制化制造。In order to fabricate a new kind of bionic and bioactive mandible substitute with customized macro-shape and similar micro-structure to that of a human bone, a new kind of manufacturing process for bionic bone substitute based on rapid prototyping was proposed, which could rapidly shape the 3D bionic scaffold and the prototype of the frame of the customized implant. Then Ti found technology was used to form the Ti frame. The 3D bionic scaffold in the Ti frame was surrounded by calcium phosphate cement coupled with bone morphogenetic protein. The results showed that this kind of bionic mandible substitute has been fabricated successfully and put into clinical use. Although the case was given from a patient's mandible, rapid prototyping is suitable to the fabrication of other bionic artificial implants.

关 键 词：快速原型 下颌骨 仿生 定制 微观结构 

分 类 号：R318.01[医药卫生—生物医学工程] R739.8[医药卫生—基础医学]