有抗肿瘤活性的青蒿B衍生物  

DERIVATIVES OF ARTEANNUIN B WITH ANTILEUKEMIA ACTIVITY

作　　者：邓定安[1] 许承辉[1] 蔡俊超 

机构地区：[1]中国科学院上海药物研究所,上海200031

出　　处：《药学学报》1992年第4期317-320,共4页Acta Pharmaceutica Sinica

摘　　要：从菊科值物黄花蒿(Artemisia annua L.)中分离得到的青蒿B(arteannuin B)是一个有α-次甲基五元环倍半萜内酯化合物。文献报道一些α-次甲基环内酯萜类化合物具有抗肿瘤活性,如模地胆宁(molephantinin)。Arteannuin B (I) was converted to hydroxy lactones (Ⅶ, Ⅷ) by amixture of formic acid and sulfuric acid. Compound Ⅵ and Compound Ⅶ both showedactivity against leukemia P 388 cell in vitro. The rate of growth inhibition were 97.5%and 11.8% for(Ⅵ)and 80% and 52.6% for(Ⅶ)at the concentration of 10 and 1μg/mlrespectively. It seems that the antileukemia activity of 6- membered lactone is higher thanthat of 5- membered and the methylene group is necessary for the antileukemia activity.

关 键 词：黄芪蒿 青蒿B 抗肿瘤作用 

分 类 号：R282.710.5[医药卫生—中药学]