碘杂环化合物IHC-72、利多卡因及维拉帕米抗心律失常作用的比较  

COMPARISON OF ANTIARRHYTHMIC EFFECTS OF IHC-72(AN IODONIUM-72),LIDOCAINE AND VERAPAMIL

作　　者：姬广聚[1] 赵德化[1] 刘德强[1] 盛宝恒 

机构地区：[1]第四军医大学药理教研室

出　　处：《药学学报》1992年第6期407-411,共5页Acta Pharmaceutica Sinica

摘　　要：在大鼠和豚鼠整体模型上,比较观察了等毒剂量(1/ LD_(50))的IHC-72、利多卡因和维拉帕米对乌头碱、哇巴因致心脏毒性的保护作用,以及对急性缺血再灌注心律失常和缺血心肌室颤阈的影响。IHC-72抗乌头碱致大鼠心脏毒性作用,与利多卡因相当,而比维拉帕米强;IHC-72抗哇巴因致豚鼠心脏毒性作用,与利多卡因相当而比维拉帕米弱;对提高大鼠缺血电室颤阈值的作用,IHC-72比利多卡因及维拉帕米弱;对预防大鼠急性缺血再灌注的心律失常作用,三者作用近似。The antiarrhythmic actions of 3,6 - dimethylamino - dibenzopyridoniumedetate ( IHC-72), lidocaine (Lid) and verapamil (Ver) on several models Werecompared at equitoxic doses (equal fraction of LD_(50)) . The action of IHC- 72 againstaconitine induced arrhythmia was similar to that of Lid but stronger than that of Ver inanesthetized rats. The effect of IHC- 72 on ouabain induced arrhythmia was also similarto that of Lid, but weaker than that of Ver in anesthetized guinea pigs. The activity ofIHC- 72 to raise electrical ventricular fibrillation thresholds (VFT) was weaker than thatof Lid and Ver. The effects of IHC-72 in decreasing the incidence of ventricular prema-ture beat(VP B), ventricular tachycardia (VT), ventricular fibrillation (VF) andshotenning the duration of VT yielded by reperfusion were similar to those of Lidanf Ver in vivo.

关 键 词：利多卡因 维拉帕米 心律失常 

分 类 号：R972.2[医药卫生—药品]