莲心碱对大鼠血流动力学及兔心房特性的影响  

EFFECTS OF LIENSININE ON HAEMODYNAMICS IN RATS AND THE PHYSIOLOGIC PROPERTIES OF ISOLATED RABBIT ATRIA

作　　者：王嘉陵[1] 农艺[1] 江明性[1] 

机构地区：[1]同济医科大学药理教研室,汉口430030

出　　处：《药学学报》1992年第12期881-885,共5页Acta Pharmaceutica Sinica

摘　　要：iv莲心碱(Lien)3mg/kg可一过性地抑制麻醉或毁脊髓大鼠血流动力学诸指标,对麻醉大鼠LVP,+dp/dt_(max)及SAP的抑制较奎尼丁(Qui)3mg/kg为强;Lien 1～30 mg/kg可依量性地产生上述效应,12mg/kg的Lien和Qui分别使LVP,+dp/dt_(max),SAP下降33％,37％,29％和9％,12％,9％,而二者对其它血流动力学参数的抑制程度却相近。Lien 12 mg/kg对血流动力学诸指标的抑制强度与维拉帕米(Ver)1 mg/kg相似。Lien 1～100μmol/L可浓度依赖性地抑制左房收缩力和右房频率。提示其对血流动力学影响的特性与Ver更相似而与Qui有别。Liensinine(Lien), an alkaloid extracted from the green seed embryo of Nelumbo nucifera Gaertn, has been shown to have anti-arrhythmic action, its mechanism may be related toblockade of Ca^(2+),Na^+ influx. Lien 3 mg/kg iv may temporarily inhibit all parameters of haemo-dynamics in anesthetized or pithed rats. The inhibitory effects on LVP, +dp/dt_(max), and SAP in anes-thetized rats are slightly stronger than those of quinidine(Oui) 3 mg/kg. Lien 1～30 mg/kg dose-de-pendently produced these actions. Lien and Qui 12 mg/kg lowered LVP, +dp/dt_(max), and SAP by33%, 37%, 29% and 9%, 12%, 9% respectively. While both of them inhibited the other param-eters of haemodynamics with nearly equal degrees. The degrees of inhibitory effect of Lien 12 mg/kgon all haemodynamic parameters nearly corresponded to these of verapamil 1 mg/kg. Lien 1～100μmol/L reduced the contractile force of isolated left atria and the spontaneously beating rate of isolatedright atria of rabbits in concentration-dependent manner. Thes esults indicate that the properties of the effect of Lien on haemodynamics may be similar to those of verapamil and different from those ofQui.

关 键 词：莲心碱 维拉帕米 血流动力学 药理 

分 类 号：R972.2[医药卫生—药品]