奈替米星对老年患者血尿系列微量蛋白的影响  

Effects of Netlimicin on a Series of Microproteins in Elder Patients

作　　者：潘丽萍[1] 王鸣和[1] 余海[1] 黎敏[1] 孙育民[1] 陆之谨[1] 尹妮[2] 赵敏华[3] 

机构地区：[1]上海市静安区中心医院内科,上海200040 [2]上海市静安区中心医院检验科,上海200040 [3]上海市静安区中心医院药剂科,上海200040

出　　处：《实用临床医学（江西）》2004年第1期22-23,26,共3页Practical Clinical Medicine

摘　　要：目的 :探讨奈替米星治疗后对老年患者早期肾功能的影响。方法 :测定 36例经奈替米星治疗老年患者用药前和用药后第 7天血转铁蛋白 (TRF)、β2 微球蛋白 (β2 MG)和肌酐 (Cr) ,尿微量白蛋白 (mAlb)和尿α1 微球蛋白 (α1 MG)。用药第 7天检测奈替米星血药谷、峰浓度。结果 :用药前血TRF、β2 MG、Cr,尿mAlb、尿mAlb/Cr、尿α1 MG及α1 MG/Cr分别为 (2 .5 4± 0 .2 1)g/L、(3.2 4± 1.75 )mg/L、(6 1.92± 15 .77) μmol/L、(4 1.5 8± 5 2 .4 3)mg/L、(12 .2 0± 14 .79)g/mol、(35 .2 1± 2 7.11)mg/L和 (12 .5 2± 10 .0 7)g/mol;用药后分别为 (2 .5 6± 0 .35 )g/L、(3.4 8± 1.70 )mg/L、(6 2 .5 0±17.39) μmol/L、(4 2 .86± 6 2 .10 )mg/L、(13.2 1± 14 .7)g/mol、(4 0 .71±2 8.31)mg/L和 (15 .98± 12 .4 3)g/mol。治疗后血TRF、β2 MG、Cr和尿mAlb较治疗前的差别无显著性 (P >0 .0 5 ) ;治疗后尿α1 MG、尿mAlb/Cr和尿α1 MG/Cr较治疗前升高 ,有统计学差异 (P <0 .0 5 ,<0 .0 5 ,<0 .0 1)。奈替米星血药峰、谷浓度分别为 (6 .6 9± 2 .2 7)、(0 .4 8± 0 .4 3) μg/ml。结论 :血尿系列微量蛋白可作为老年患者奈替米星治疗期早期肾毒性的标志物。Objective:To study effects of netilmicin on the early renal function in elder patients.Methods:serum transferrin (TRF),β 2-microglobin(β 2-MG),creatinine(Cr)and urinary microalbumin (mAlb) and α 1-miroglobin(α 1- MG) were measured in 30 elder patients received netilmicin before and at 7 days after the treatment. Plasma concentration of netilmicin was detected at 7 days after treatment.Results:TRF,β 2-MG,Cr,mAlb,mAlb/Cr,α 1-MG and α 1-MG/Cr before treatment were (2.54±0.21)g/L,(3.24±1.75)mg/L,(61.92±15.77)μmol/L,(41.58±52.43)mg/L,(12.20±14.79)g/mol,(35.21±27.11)mg/L and(12.52±10.07)g/mol.After treatment, those were (2.56±0.35)g/L,(3.48±1.70)mg/L,(62.50±17.39)μmol/L,(42.82±62.10)mg/L,(13.21±14.75)g/mol,(40.71±28.31)mg/L,(15.98± 12.43 )g/mol.TRF,β-MG,Cr and urinary mAlb were not significant different between two time points (P< 0.05 ,<0.05,<0.01).Urinary α 1-MG,mAlb/Cr and α 1-MG/Cr were significantly higher after treatment than those before treatment.The peak and trough concentration of netilmicin were(6.69±2.27)μg/ml and(0.48±0.43)μg/ml.Conclusion:A series of microproteins are more sensitive indicator of the early renal damage during treatment of netilmicin in elder patients.

关 键 词：奈替米星 微量蛋白 肾毒性 

分 类 号：R978.12[医药卫生—药品]