聚乙二醇对尼莫地平溶解性能的影响  

The Effects of PEG on the Solubility of Nimodipine

作　　者：郭圣荣[1] 张芳[1] 张亚琼[1] 郭丽[1] 赵凤生[1] 

机构地区：[1]上海交通大学药学院,上海200030

出　　处：《上海交通大学学报》2004年第2期312-315,共4页Journal of Shanghai Jiaotong University

摘　　要：测定了尼莫地平(nimodipine,NM)在聚乙二醇(PEG)的磷酸缓冲溶液中的溶解度;用熔融法制备了NM-PEG-6000固体分散体(SD);由差热分析(DSC)和X射线衍射(XRD)分析鉴别药物在载体中的存在状态,并进行体外溶出度测定.结果表明,随PEG浓度增大,NM的溶解度增大;NM以微细结晶存在于PEG中;随着SD内PEG比例的增大,NM的释药速率明显增大,而且2h的累积溶出度也增大.因此,PEG对NM有增溶作用;NM-PEG-6000固体分散体和物理混合物可提高药物的溶出速率.The nimodipine(NM) solid dispersions(SD) were prepared by solvent-melting; DSC and X-ray powder diffractometry were used to determine the status of NM in carriers, and in vitro dissolution characteristics were studied. The results show that the solubility of NM increases with the PEG concentration; the drug in solid dispersions exists in microcrystalline form; the dissolutions of the solid dispersions are much more than that of the pure drug.

关 键 词：尼莫地平 聚乙二醇-6000 溶出度 固体分散体 

分 类 号：R944.2[医药卫生—药剂学]