中国南方汉族人MMP-9基因多态性与COPD易感性的关系  

Correlation between genetic polymorphism in MMP-9 and susceptibility to COPD in southern Chinese population of Han nationality of China

作　　者：周敏[1] 黄绍光[1] 万欢英[1] 李彪[1] 李敏[1] 程齐俭[1] 

机构地区：[1]上海第二医科大学瑞金医院肺科,上海200025

出　　处：《上海第二医科大学学报》2004年第2期81-84,共4页Acta Universitatis Medicinalis Secondae Shanghai

基　　金：国家"十五"科技攻关项目(2001BA703B03)

摘　　要：目的 探讨中国南方汉族人基质金属蛋白酶-9(MMP-9)基因多态性与慢性阻塞性肺疾病(COPD)易感性的关系。方法 应用限制性片段长度多态性(RFLP)技术,检测MMP-9启动子基因型在100例COPD患者和98例健康吸烟者中的频率。结果 COPD中同源野生型(C/C)、杂合型(C/T)频率分别是86％、14％,健康人的频率分别是98％、2％,两组基因频率分布差异具有显著性(P<0.01)。等位基因C频率分别是93％比99％,等位基因T频率分别是7％比1％,两组等位基因的分布差异也具有显著性(P<0.05)。结论 MMP-9启动子-1562位的多态性可能与中国南方汉族人群COPD易感性相关。Objective To investigate the correlation between matrix metalloproteinase-9 ( MMP-9) gene polymorphism and chronic obstructive pulmonary disease (COPD) susceptibility in Chinese population of Han nationality of southern China. Methods Examine the frequency of the genetype of the promoter of MMP-9 (-1562C/T) in 100 COPD patients and 98 smoking control subjects without COPD by restriction fragment length polymorphism. Results The frequencies of polymorphic genotypes in promoter of MMP-9 in the COPD group were C/C 86% and C/T 14% , and the frequencies of polymorphic genotypes in control group were C/C 98% and C/T 2% , There were significant differences between the two groups(P <0. 01) . The differences in allele frequencies were also significant between the two groups (C allele frequency : 93% vs 99% , T allele frequency: 7% vs 1% , P < 0. 05). Conclusion The genetic polymorphism in promoter of MMP-9 gene was associated with susceptibility to COPD in the Chinese population of Han nationality of southern China.

关 键 词：中国南方 汉族人 MMP-9 基因多态性 COPD 易感性 

分 类 号：R563.9[医药卫生—呼吸系统]