先天性与获得性乙肝标志物模式及其各指标含量表达与肝纤维化形成的关系  

Correlation Between Hepatic Fibrosis and Modes of Combination as well as Contents of the Six Hepatitis B Markers in Patients with Acquired or Congenital Hepatitis B

作　　者：薛鲜娥[1] 陈然峰[1] 陈孟春[1] 黄志勇[1] 黄晓文[1] 章喜诚[1] 

机构地区：[1]武警浙江总队医院检验科,314000

出　　处：《放射免疫学杂志》2004年第1期11-13,共3页Journal of Radioimmanology

摘　　要：目的 :探讨先天性与获得性乙肝标志物模式及其各指标含量表达与肝纤维化形成的关系。方法 :采用放射免疫分析对先天性乙肝 4 8例、获得性乙肝 1 4 9例、单一HBsAg阳性HBV携带者 1 1例和健康对照 4 9例的乙肝血清标志物 (HBsAg、HBsAb、HBeAg、HBeAb、HBcAg和HBcAb)与肝纤维化指标 (HA、LN、PⅢ和Ⅳ .C)的含量作了检测 ,根据乙肝模式与含量进行分组比较分析。结果 :1 先天组HA、LN、PⅢ和Ⅳ C的平均含量 [(1 4 1 6± 4 6 1 )、(1 4 0 4± 6 6 1 )、(1 30 2± 30 6 )和 (6 6 7± 1 5 1 ) μg/L]低于获得组 [(1 5 9 6± 5 5 2 )、(1 6 4 8± 76 1 )、(1 5 0 6± 5 9 1 )和 (88 4± 2 7 1 ) μg/L](p均 <0 0 5 )。 2 在先天组或获得组内 ,大、小三阳比较 ,LN、PⅢ、Ⅳ C的p值均>0 0 5 ,无显著差异。 3 先天组的HA、LN、PⅢ、Ⅳ C含量与HBsAg浓度的升高不呈正相关。但在获得组内 ,随着HBsAg浓度升高而呈梯式上升。结论 :1 获得性乙肝的肝细胞损伤程度较先天性乙肝重。 2 大、小三阳的肝细胞损伤严重程度无显著差异。 3 获得性乙肝组的HBsAg含量与肝纤维化形成呈正相关。但在先天组 ,HA、LN、PⅢ、ⅣObjective To investigate the relationship between development of hepatic fibrosis and the modes of combination as well as the contents of the six hepatitis markers in patients with congenital or acguired hepatitis β. Methods The contents of six serum hepatitis β markers (HBsAg, HBeAb, HBcAg, HBcAb) and 4 hepatic fibroisis indicators (HA, LN, PⅢ and Ⅳ-C) were measured with RIA in 48 patients with congenital hepatitis β, 149 patients with acquired hepatitis β and 11 HBV carriers (HBsAg + only) as well as 49 controls. Results 1 Serum levels of HA, LN, PⅢ and Ⅳ-C in congenital group were 141 6±46 1, 140 4±66 1, 130 2±30 6 and 66 7±15 1μg/L respectively, which were significantly lower than those in acquired group (159 6±55 2, 164 8±76 1, 150 6±59 1 and 88 4±27 1μg/L, p <0 05). 2 In both groups, whatever the modes of combination of the positive markers were (eg. HBsAg +, HBeAg +, HBcAb + or HBsAG +, HBeAb +, HBcAb + or others), the corresponding contents of the hepatic fibrosis indicators were not much different ( p >0 05). 3 The contents of the 4 indicators in acquired group increased with increasing HBcAg concentration, but not so in the congenital group. Conclusion 1. Hepatocyte injury was more serious in acquired hepatitis. 2. The degree of hepatocyte injury was about the same with different combination modes of positive markers. 3. In patietns with acquired hepatitis, the expression of HBsAg was positively correlated to the degree of hepatic fibrosis but not so in the congenital group.

关 键 词：获得性乙型肝炎 先天性乙型肝炎 血清标志物 肝纤维化 放射免疫分析 肝细胞损伤 

分 类 号：R512.62[医药卫生—内科学]