养心通脉片对胰岛素抵抗综合征大鼠红细胞胰岛素受体的影响  

EFFECTS OF YANGXIN TONGMAI TABLETS ON RYTHROCYTE INSULIN RECEPTOR OF INSULIN RESISTANCE SYNDROME IN RATS

作　　者：黄献平[1] 袁肇凯[1] 卢芳国[1] 田松[1] 谢梦洲[1] 王东生[1] 胡志希[1] 

机构地区：[1]湖南中医学院中医诊断研究所,湖南省长沙市410007

出　　处：《中国心血管病研究》2004年第3期220-223,共4页Chinese Journal of Cardiovascular Research

基　　金：湖南省教育厅重点项目(No.99A03)

摘　　要：目的 研究养心通脉片对胰岛素抵抗综合征(IRS)大鼠模型胰岛素受体的影响。方法 采取“高脂高糖高盐膳食”饲养法复制实验性IRS大鼠模型。设养心通脉组、二甲双胍组、病理模型组、健康对照组,治疗30d,观察比较4组大鼠模型“高亲和力红细胞受体的结合胰岛素位点数(EIR-H)”和“低亲和力红细胞受体的结合胰岛素位点数(EIR-L)”。结果 IRS病理模型组大鼠的EIR-H和EIR-L的检测值均显著低于健康对照组及二治疗组(P均<0.01),4组大鼠比较,EIR-H和EIR-L二项指标都呈现健康对照组→养心通脉组→二甲双胍组→病理模型组递减的趋势(P均<0.01);二治疗组比较,养心通脉组的EIR-H和EIR-L较之二甲双胍组均显著升高(P<0.01或P<0.05)。结论 IRS时,胰岛素受体浓度及亲和力均有明显下调,养心通脉片对EIR的上调作用明显优于二甲双胍片。Objective To study the effect of Yangxin Tongmai Tablets(YTT) on insulin receptor of Insulin Resistance Syndrome(IRS) of rats model. Methods We fed the 'high fat and high sugar and high salt meal' to replicate the IRS model, and divided them into four groups: Yangxin Tongmai Tablets group(YTTG), Metform Tablets group(MFTG), Pathology Model group(PLMG), Normal group (NG). After 30 days, the number of High affinity of erythrocyte insulin receptor(EIR - H) combination and Low affinity of erythrocyte insulin receptor (EIR- L) combination were compared to those in the beginning among 4 group rat models. Results After treatment, EIR- H and EIR- L of PLMG both showed significant lower than the NG and the 2 treatment groups(P<0. 01) ,4 groups were compared,2 indexes of EIR- H and EIR- L present a NG→YTTG→MFTG→PLMG gradually decreasing trend(P < 0. 01); 2 treatment groups were compared, EIR - H and EIR - L of YTTG showed significant higher than the MFTG(P < 0.01 or P< 0.05). Conclution When IRS,the density of insulin receptors and their affinity show significant decrease, the effect of YTT on the increase of EIR is better than MFT.

关 键 词：养心通脉片 胰岛素抵抗综合征 大鼠 红细胞 胰岛素受体 IRS 心血管疾病 

分 类 号：R286[医药卫生—中药学] R-332[医药卫生—中医学]