人胚胎期前庭水管生长发育模式分析  

Analysis of growth model in vestibular aqueduct during human fetal development

作　　者：雷雳[1] 韩德民[1] 于振坤[2] 诸小侬[2] 刘莎[2] 陈树斌[1] 范尔钟[2] 

机构地区：[1]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科,北京100730 [2]北京市耳鼻咽喉科研究所

出　　处：《中华耳鼻咽喉科杂志》2003年第4期275-278,I005,共5页Chinese Journal of Otorhinolaryngology

摘　　要：目的　探讨人胚胎期前庭水管生长发育特征 ,以便更好地理解前庭水管扩大的起源。方法　应用 3DMed医学图像分析软件对 6～ 3 8周 (每隔 1周 2例 )的 3 2具人胎儿颞骨连续组织病理切片进行观察分析 ,测量不同胎龄前庭水管内口、外口、中点直径和管长度 ,经曲线拟合描述其生长发育模式。结果　胚胎 6周时 ,前庭水管内口已发育形成。胚胎 10周 ,前庭水管生长延伸至后颅窝的岩锥后壁。到胚胎 3 8周 ,管径各参数均值小于成人前庭水管直径平均值。统计分析显示 ,随胎龄变化前庭水管内口、外口、中点直径呈非线性生长 ,生长曲线无稳定走向趋势 ,仅长度随胎龄增大而增长。结论　整个胚胎期前庭水管处在不断发育过程中 ,出生时横向直径均值无一达成人水平 ,提示 。Objective To characterize the growth of the developing vestibular aqueduct in order to gain a better understanding of the possible origins of enlarged vestibular aqueduct Methods Serial sections from 32 temporal bones for every other week from human embryos ranging in age from 6 to 38 weeks were studied with 3DMed medical image analysis software The internal, external aperture, midpoint diameter and length vestibular aqueduct were analyzed with regression analysis to obtain a growth curve Results The internal aperture of vestibular aqueduct was began to form at 6 weeks′ gestation It grew to reach the posterior surface of the petrous bone in the posterior cranial fossa by 10 weeks′ gestation All width parameter mean value in our embryos nerve reached the maximum average width in the adult Statistical analysis showed that the vestibular aqueduct grew in a nonlinear continuous fashion and instability trend throughout embryonic life, except length parameter Conclusion The vestibular aqueduct grows in a nonlinear fashion throughout embryonic life The widest aqueduct measured in embryonic life does not reach the maximum average width in the adult These results suggest that it would be possible for vestibular aqueduct to develop postnatally

关 键 词：前庭水管 胚胎期 生长发育模式 感音神经性聋 组织形态学 

分 类 号：R764[医药卫生—耳鼻咽喉科]