淫洋藿总黄酮对大鼠血清中ACE,NO及ET含量的影响  

To Explore the Effects of Total Flavones of Epimedium on Angiotensin Converting Enzyine and Nitric Oxide and Endothelin in Rats Plasma

作　　者：许兰芝[1] 耿秀芳[1] 冯秀香[1] 郭方明[1] 

机构地区：[1]潍坊医学院药理学教研室,山东潍坊261042

出　　处：《潍坊医学院学报》2003年第5期334-335,共2页Acta Academiae Medicinae Weifang

摘　　要：目的　观察淫洋藿总黄酮对大鼠血清中血管紧张素转化酶 (ACE)、一氧化氮 (NO)及内皮素 (ET)含量的影响。方法　用紫外分光光度法和放射免疫学方法 ,测定淫洋藿总黄酮 (大剂量组 2 0 0mg kg·d ;小剂量组10 0mg kg·d ;腹腔注射 ,用药 7d后 )对大鼠血清中ACE ,ET的活性及NO含量的影响。结果　淫洋藿总黄酮对ACE活性无影响 (P >0 .0 5 ) ;对ET有抑制作用 (P <0 .0 1) ;NO含量明显降低 (P <0 .0 1)。结论　淫洋藿总黄酮的降压作用与其降低血浆内皮素的含量有关。Objective To explore the effects of total flavones of epimedium on nitric oxide(NO),endothelin(ET),and angiotensin converting enzyine(ACE) in rats' plasma.Methods NO,ET and ACE in rats' blood serum were measured with UV chromatography and radiodmmunoassay method.Results The TFE could not inhibit the activation of ACE in vivo,but could significantly decrease the content of ET (from154.92±20.45ng/L to 121.75±10.71 ng/L,P<0.05 ) and NO (from 201.11±24.10μmol/L to 106.9±8.59μmol/L,P<0.01).Conclusion Antihypertentsion mechanism of TFE is related to decreasing the content of ET and blocking β_1 receptor selectively.

关 键 词：淫洋藿总黄酮 血管紧张素转化酶 内皮素 一氧化氮 

分 类 号：R392.33[医药卫生—免疫学] R961[医药卫生—基础医学]