甲状腺重量及血清TSH浓度对小剂量^(131)I治疗甲亢疗效的影响  

Effects Thyroid Weight and Serum TSH on the Results of Hyperthyroidism Treated with ^(131)I

作　　者：张又平[1] 徐新女[2] 秦岚[1] 秦明秀[1] 

机构地区：[1]天津市第一中心医院核医学科,天津300192 [2]卫生部危重病急救医学重点实验室

出　　处：《解剖与临床》2003年第2期81-83,共3页Anatomy and Clinics

摘　　要：目的 :评价甲状腺重量及血清TSH浓度对小剂量1 3 1 I治疗甲状腺功能亢进症 (甲亢 )疗效的影响。方法 :患者治疗前均行甲状腺SPECT扫描并检测血清FT3、FT4、TSH浓度 ;1 3 1 I治疗的剂量为常规剂量的 1 2～ 2 3。结果 :①治疗前一次给药组TSH浓度为 0 .10± 0 .34mμ·L- 1 ,重复给药组为 0 .0 4± 0 .10mμ·L- 1 ,两者差异有显著性 (P <0 .0 5 ) ;②治疗前甲状腺的重量一次给药组为 5 1.2 2± 2 6 .0 9g ,重复给药组 87.34± 6 3.6 9g ,两者差异有显著性 (P <0 .0 0 0 1)。结论 :小剂量1 3 1 I治疗甲亢的疗效良好 ,多数患者能一次治愈 ,但对于大甲状腺患者或血清TSH浓度很低者则需多次治疗。Objective:To evaluate effects of thyroid weight and serum TSH on the results of hyperthyroidism treated with 131 I in a small amount of dosage.Methods:Each patient was treated with 131 I in a 1/2～2/3 of routine dosage after SPECT scan on the thyroid was done and FT3,FT4,TSH in blood serum were detected.Results:(1)TSH of the patients in the singly treated group was 0.10±0.34mμ·L -1 and was 0.04±0.10mμ·L -1 in the repeatedly treated group before they were treated with 131 I.There occurred a significant difference between them(P<0.05).(2)The weight of thyroid in the singly treated group was 51.22±26.09g and in the repeatedly treated group was 87.34±63.69g,presenting with a significant difference(P<0.0001).Conclusion:The treatment of hyperthyroidism with 131 I in a small amount of dosage may induce good results and most of the patients can be cured in a single time,but for the patients with giant thyroid or with a very low serum TSH it is imperative to be treated several time.

关 键 词：血清TSH浓度 剂量 治疗 甲亢 甲状腺功能亢进症 SPECT扫描 

分 类 号：R581.1[医药卫生—内分泌]