美托拉宗的NMR数据解析  

A NMR STUDY OF METOLAZONE

作　　者：董建军[1] 吴鸣建[1] 张海艳[1] 付经国[1] 陈涛 赵天增[1] 

机构地区：[1]河南省生物技术开发中心,河南郑州450002 [2]西安力邦企业,陕西西安750015

出　　处：《波谱学杂志》2004年第1期93-97,共5页Chinese Journal of Magnetic Resonance

摘　　要：对美托拉宗进行了~1H和^(13)C MNR检测,通过DEPT和HMQC、HMBC等2D NMR技术对其~1H和^(13)C NMR数据进行了全归属和详细的解析,并指出其NMR数据特征。Metolazone is a well-known quinazolinone diuretic widely used for the treatment of congestive heart failure and high blood pressure. Metolazone was first synthesized in 1967 with its first detailed pharmacological evaluation done in 1969. Previous results only reported part of its ~1H NMR data, and the detailed elucidation is yet to be performed. In this paper, using a combination of 1D and 2D NMR techniques, the ~1H and ^(13)C NMR spectra of metolazone were completely assigned and analyzed. The characteristics of its NMR data were also discussed.

关 键 词：美托拉宗 核磁共振 构象异构体 利尿剂 结构分析 分子结构 

分 类 号：R917[医药卫生—药物分析学] O482.532[医药卫生—药学]