镉中毒致肺损伤的病理形态学观察  

Pathologic survey on lung impairment induced by cadmium poisoning

作　　者：周桂凤[1] 贺全仁[2] 

机构地区：[1]湖南医学高等专科学校劳动卫生教研室,长沙市410006 [2]中南大学公共卫生学院卫生毒理研究室

出　　处：《职业与健康》2004年第1期4-5,共2页Occupation and Health

摘　　要：目的　观察经血循环系统转运至肺脏的镉对肺组织的损伤作用。方法　通过对大鼠亚急性腹腔注射氯化镉 ,测定大鼠肺组织中镉含量 ,观察其肺组织病理形态学改变。结果　氯化镉组大鼠肺组织镉蓄积 (11 42± 1 0 6) μg/g ,比对照组高14 5 4倍 (t =3 3 .83 ,P <0 .0 1) ,肺组织病理形态观察显示 ,肺泡Ⅱ型上皮细胞、毛细血管内皮细胞受损 ,肺泡间隔增厚 ,间质纤维增生。结论　亚急性腹腔注射染镉可以在大鼠肺内高度蓄积 ,并使肺组织产生病理改变。Objective To observe lung impairment induced by cadmium passing through blood circulation system to lung.The cadmium contents in rat lungs were determined by subacute intra-abdominal injecting CdCl2 (1.4 mgCd/kg, three times a week for 6 weeks) and the histopathologic survey on lung was also carried out.The cadmium contents in rat lung 〔 (11.42 ± 1.06) μg/g〕 are 145.4 times more than that of control group ( t =33.83, P <0.01). The histopathologic survey on lung shows the impairment of II alveolar epithelial tissue and capillary endothelial cell, the thickening of alveolar septa, and interstitial fibers proliferation.[Conclusion]Subacute intra-abdominal injection of CdCl2 can induce cadmium accumulation in lung and pathologic changes in lung tissue.

关 键 词：镉 肺损伤 病理形态 大鼠 

分 类 号：R114[医药卫生—卫生毒理学]