碘硒联用对氟致大鼠学习记忆损伤及血液生化指标的影响  

Effect of iodine and selenium on learning memory impairment induced by fluorosis and blood biochemical criterion of rats

作　　者：申秀英[1] 章子贵[1] 许晓路[2] 

机构地区：[1]浙江师范大学生命与环境科学学院,浙江省金华市321004 [2]绍兴文理学院

出　　处：《职业与健康》2004年第1期6-8,共3页Occupation and Health

基　　金：浙江省自然科学基金资助课题 (30 1 4 67)

摘　　要：目的　研究碘、硒对氟致大鼠学习记忆行为损伤及血液生化指标变化的影响 ,探讨碘、硒对氟中毒的拮抗作用。方法　氟中毒大鼠长期饮用不同浓度的碘和硒后 ,用Y -迷宫观测其学习记忆力 ,同时测定其血液内的一些生化指标。结果　高氟组、高碘高氟组和低碘高氟组大鼠学习记忆能力显著降低 ,而高氟同时加入适当浓度的碘或硒组大鼠的学习能力显著提高 ;上述各组大鼠血液内的一些生化指标也有一些显著性变化。结论　适当浓度的碘、硒对大鼠氟中毒有明显的拮抗作用。而且这种拮抗作用可能与血液中的一些生化指标的变化有关。Objective To investigate the effect of iodine and selenium on learning memory behavior impairment induced by fluorosis and blood biochemical criterion change of rats. To study the antagonism of iodine and selenium on fluorosis. After the rats with fluorosis drinking water with different concentrations of iodine (I) and selenium (Se) for a long time, their learning memory abilities were measured by way of Y-maze, and the blood biochemical criterions were determined at the same time. The learning memory abilities of rats in high F group, high I - high F group, and low I - high F group were significantly lower than control group, while the learning memory abilities of rats given proper concentration I and Se increased significantly. The blood biochemical criterions of high F group, high I - high F group, and low I - high F group presented marked differences from that of groups given proper concentration I and Se.[Conclusion]Proper concentration I and Se have obvious antagonism against rat fluorosis. The antagonism may be related with the changes of blood biochemical criterion.

关 键 词：碘 硒 氟中毒 学习记忆 血液生化指标 

分 类 号：R114[医药卫生—卫生毒理学]