尼卡地平与拉贝洛尔控制腹腔镜手术中高血压的效果  

Nicardipine and labetalol in controlling hypertension during laparoscopic cholecystectomy

作　　者：孙继雄[1] 唐淑蕙 王亚华[2] 石学银[2] 

机构地区：[1]上海市东方医院麻醉科,上海200120 [2]第二军医大学长征医院麻醉科,上海200003

出　　处：《第二军医大学学报》2004年第2期220-222,共3页Academic Journal of Second Military Medical University

摘　　要：目的 :比较尼卡地平与拉贝洛尔对伴高血压的腹腔镜手术患者气腹期间的降压效果。 方法 :将 30例择期行腹腔镜下胆囊切除术患者 (均有高血压病史 )随机分成 3组 ,对照组仅接受麻醉药 ;尼卡地平组诱导前 3min静注尼卡地平 2 0 μg· kg- 1·min- 1 ,随后持续静注 0 .5～ 1 .5μg· kg- 1 · m in- 1 ;拉贝洛尔组诱导前 3m in静注拉贝洛尔 0 .3m g· kg- 1 · m in- 1 ,之后持续静注 1 0～ 2 0μg· kg- 1 · m in- 1 。观察给药前后患者心率、血压及心率收缩压乘积的变化。 结果 :尼卡地平组、拉贝洛尔组收缩压、舒张压、平均动脉压和心率与对照组比较均有显著性差异 (P<0 .0 5 )。 结论 :尼卡地平与拉贝洛尔均可控制高血压患者腹腔镜手术中因吸收 CO2 引起的血压升高 。Objective: To compare the effects of nicardipine and labetalol on hypertension during laparoscopic cholecystectomy.Methods:Thirty patients with hypertension undergoing selective laparoscopic cholecystectomy were randomly divided into 3 groups. The control group was only given anesthetic drugs; nicardipine group was given nicardipine 20 μg·kg -1 ·min -1 before induction, followed by intravenous continuous infusion of nicardipine at the rate of 0.5 1.5 μg·kg -1 ·min -1 ; labetalol group received labetalol 0.3 mg·kg -1 ·min -1 before induction followed by intravenous continuous infusion of labetalol at the rate of 10 20 μg·kg -1 ·min -1 . Results: Statistical differences( P <0.05) were found in SBP and DBP among 3 groups.The effect of 2 drugs were prompt,safe,and with less side effects. Conclusion: Both nicardipine and labetalol can treat the hypertensive response to CO 2 in the patients with hypertension during laparoscopic cholesystectomy.

关 键 词：尼卡地平 拉贝洛尔 腹腔镜 药物治疗 高血压 降压药 气腹 外科手术 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]