新的手性膦配体的合成及其在苯乙烯不对称氢酯基化中的应用  

Synthesis of new chiral phosphine ligands and their applicationsin the asymmetric hydroesterification of styrene

作　　者：陈敏东[1] 郑有飞[1] 徐建强[1] 孙伟[2] 吕士杰[2] 华维一[3] 

机构地区：[1]南京气象学院环境科学系,江苏南京210044 [2]中国科学院兰州化物所羰基合成与选择氧化国家重点实验室,甘肃兰州730000 [3]中国药科大学药学院,南京江苏210009

出　　处：《化学研究与应用》2004年第1期131-132,共2页Chemical Research and Application

基　　金：国家自然科学基金资助项目(29933050;40175029);南京气象学院自然基金资助项目。

摘　　要：Two new chiral phosphine ligands,1,4∶3,6-dianhydro-2,5-O-dideoxy-2,5-bis(dipheny-phosphinoxy)-L-iditol and 1,4∶3,6-dianhydro-2,5-O-dideoxy-2,5-bis(dipheny-phosphinsulphur)-L-iditol were prepared from D-mannitol.Palladium catalytic systems formed with these ligands in situ were used as asymmetric homogenous catalysts for hydroesterification of styrene,giving(R)-2-phenyl propionate in 16.9 and 9.2% ee values,respectively.Two new chiral phosphine ligands,1,4∶3,6-dianhydro-2,5-O-dideoxy-2,5-bis(dipheny-phosphinoxy)-L-iditol and 1,4∶3,6-dianhydro-2,5-O-dideoxy-2,5-bis(dipheny-phosphinsulphur)-L-iditol were prepared from D-mannitol.Palladium catalytic systems formed with these ligands in situ were used as asymmetric homogenous catalysts for hydroesterification of styrene,giving(R)-2-phenyl propionate in 16.9 and 9.2% ee values,respectively.

关 键 词：手性膦配体 合成 苯乙烯 不对称氢酯基化反应 甘露醇 催化活性 

分 类 号：O643.36[理学—物理化学] O625.12[理学—化学]