N,N′-二(糖基硫代亚脲基)芳基硫代膦酰二胺的合成  

Synthesis of N,N′-Di(glycosylthioureylene) arylthiophosphonic diamides

作　　者：曹玲华[1] 周传健[1] 

机构地区：[1]新疆大学化学化工学院化学系

出　　处：《应用化学》2004年第3期239-242,共4页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金 (2 9962 0 0 2 );南开大学元素有机化学国家重点实验室基金资助项目

摘　　要：芳基硫代膦酰二氯 (2a～ 2c)由二氯芳基膦 (1a～ 1c)与PSCl3 反应得到 ,肼解后得到芳基硫代膦酰二肼 (3s～ 3c) ,将它们分别与糖基异硫氰酸酯 (4a～ 4e)在苯中回流 ,生成相应的N ,N′ (糖基硫代亚脲基 )芳基硫代膦酰二胺 (5a～ 5e ,6a～ 6e ,7a～ 7e) ,结构经IR、1HNMR、3 1PNMR、MS和元素分析加以确证。Reactions of dichloroarylphosphine(1a～1c) with PSCl 3 gave corresponding arylthiophosphonic dichlorides(2a～2c), which after hydrazinolyzation gave arylthiophosphonic dihydrazides(3a～3c). Reactions of 3a～3c with glycosyl isothiocyanates(4a～4e) in benzene gave corresponding N,N′-di(glycosylthioureylene) arylthiophosphonic diamides(5a～5e,6a～6e,7a～7e). Their structures were confirmed by IR, 1H NMR, 31P NMR, MS and elemental analysis. The glycosyl isothiocyanates 4a～4e were prepared by the reaction of α-D-glycosyl bromides with Pb(SCN) 2. The biological activities of the representative compounds have been examined.

关 键 词：二(糖基硫代亚脲基)芳基硫代膦酰二胺 合成 糖基异硫氰酸酯 硫代膦酰二肼 生物活性 

分 类 号：O622[理学—有机化学]