咽鼓管表面活性物质对气压损伤豚鼠中耳及听阈的影响(英文)  

Effects of eustachian tube surfactant on barotitis media and auditory threshold in guinea pigs

作　　者：冯立宁[1] 陈文弦[2] 丛锐[3] 苟琳[1] 李莉[1] 郭群[1] 

机构地区：[1]解放军第四军医大学航空航天医学系 [2]解放军第四军医大学唐都医院耳鼻咽喉科,陕西省西安市710032 [3]解放军第四军医大学西京医院

出　　处：《中国临床康复》2004年第4期794-795,共2页Chinese Journal of Clinical Rehabilitation

基　　金：国家自然科学基金资助项目(39900171);军队医药卫生科研基金资助项目(98Q070)~~

摘　　要：目的:探讨人工咽鼓管表面活性物质(Eustachiantubesurfactant,ETS)对气压损伤性中耳炎(Barotitismedia,BM)的治疗作用,为临床应用提供理论依据。方法:经低压舱上升实验建立气压损伤性中耳炎动物模型。成功建模豚鼠30只,于建模后的第1天,左侧中耳内注入1mL人工ETS治疗,右侧对照注入1mL生理盐水。结果:1周后观察比较两组鼓膜状况(χ2=8.801,P<0.05)、鼓室渗出(χ2=9.796,P<0.05)、听阈恢复(χ2=9.810,P<0.05),人工ETS组明显好转,与生理盐水对照组差异有显著性意义。结论:人工ETS对气压损伤性中耳炎具有治疗作用。AIM:To study the therapeutic effect of artificial eustachian tube surfactant( ETS) on barotitis media(BM),thereby to provide theoretical basis for its clinica l application in BM treatment. METHODS:BM was successfully induced in 30 guinea pigs by simulated ascending during flight in a hypobaric oxygen chamber.The affected ears were treated by mi croinjecting 1 mL artificial ETS into the left middle ear(ETS group) through the tympanic membrane,with the right ear serving as control that was treated with 1 mL saline.Changes of the tympanic membrane,middle ear effusion and auditory thr eshold were compared. RESULTS:The condition of the tympanic membrane,middle ear effusion and audito ry threshold were obviously improved in ETS group in comparison with the control group(÷ 2=8.801,P< 0.05;÷ 2=9.796,P< 0.05;÷ 2=9.810,P < 0.05,respectively). CONCLUSION:Artificial ETS has therapeutic effect on BM.

关 键 词：咽鼓管 表面活性物质 气压损伤 豚鼠 中耳 听阈 ETS 治疗 

分 类 号：R764.82[医药卫生—耳鼻咽喉科] R-332[医药卫生—临床医学]