复方人参多糖对老年晚期非小细胞肺癌患者免疫功能和生活质量的影响  

Effect of ginseng polysaccharide compound on immunological function and quality of life in elder patients with advanced non-small cell lung cancer

作　　者：张丽辉[1] 刘旭涛[1] 陈积栋[1] 何平[2] 

机构地区：[1]解放军沈阳军区总医院干二科,辽宁省沈阳市110016 [2]中国医科大学第二附属医院干诊科,辽宁省沈阳市110003

出　　处：《中国临床康复》2004年第5期916-917,共2页Chinese Journal of Clinical Rehabilitation

基　　金：沈阳军区总医院院长基金资助课题(2003-1215号)~~

摘　　要：目的:研究复方人参多糖对老年晚期非小细胞肺癌患者免疫功能和生活质量的影响,寻求对后者有效的干预方法。方法:67例老年晚期非小细胞肺癌患者根据自愿原则选择接受复方人参多糖治疗(治疗组,34例)和不接受复方人参多糖治疗(对照组,33例)分组,复方人参多糖治疗方案为18mg,1次/d,30d为1个疗程,连续使用2个疗程,两组患者其他放、化疗方案相同,治疗前后两组患者均接受血清免疫球蛋白(Ig)、T细胞亚群和生活质量(qualityoflife,QOL)检测。结果:治疗后治疗组近期总缓解率为56%(19/34),对照组为33%(11/33),两组相差不明显(χ2=0.129,P>0.05)。治疗后治疗组IgA(1.38±0.39)g/L,IgG(11.23±3.14)g/L,IgM(1.71±0.46)g/L,明显高于治疗前,而对照组仅有IgM有明显上升(1.41±0.26)g/L;t=2.247～2.729;P均<0.05)。两组T细胞亚群指标比较中,治疗组治疗后CD3和CD4较治疗前有明显改善(t=2.778,2.547;P均<0.05),对照组全部指标无明显变化。治疗组治疗后1个月和3个月的QOL评分均较治疗前有明显改善,同时还显著优于对照组,而对后者仅治疗后3个月评分优于治疗前(t=2.230～2.491,P均<0.05)。结论:复方人参多糖对老年晚期非小细胞肺癌患者免疫功能和生活质量改善是有帮助的。AIM:To analyse the effect of ginsen polysaccharide(GP) on immunological function and quality of life(QOL) in old patients with non small cell lung cancer(NSCLC) at advanced stage. METHOD:Sixty seven elder patients with NSCLC,who were all treated according their free will,were divided into treatment group(TG) of 34 cases and control group(CG) of 33 cases.GP was used by 18 mg once a day for 60 days as two courses in the CG.GP was not used in the CG.Before and after treatment,serum determination of immunoglobulin(Ig),T lymphocyte sub groups and QOL were measured in both groups. RESULTS:After treatment,the total remission rate was 56%(19/34) in TG,which was not significantly different from that in CG(33%,11/33)(χ2=0.129,P >0.05).After treatment,the levels of IgA,IgG and IgM in TG[(1.38±0.39) g/L,(11.23±3.14) g/L and (1.71±0.46) g/L respectively]were significantly higher than those before treatment. But only the level of IgM in CG was obviously higher than that before treatment(t=2.247-2.729,all P< 0.05).Two outcome of T lymphocyte sub groups(CD3 and CD4) in DG was obviously higher than that before treatment(t=2.778,2.547,both P< 0.05),but all indexes were no changes in CG.After 1-3 months of treatment,the indices of QOL in TG were higher significantly than those before treatment and those in CG,and only after 3-month treatment,the indices of QOL in CG were higher than thaose before treatment(t=2.230-2.491,all P< 0.05). CONCLUSION:GP is effective in the improvement of immunological function and QOL in elder patiets with NSCLC.

关 键 词：复方人参多糖 老年 晚期非小细胞肺癌 免疫功能 生活质量 

分 类 号：R273.42[医药卫生—中西医结合]